57803-07-3Relevant academic research and scientific papers
One pot and metal-free approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones
Yuan, Jiaqi,He, Qian,Song, Shanshan,Zhang, Xiaofei,Miao, Zehong,Yang, Chunhao
supporting information, (2019/08/30)
Herein, a direct strategy to synthesize 3-(2-hydroxybenzoyl)-1-aza-anthraquinones with excellent efficiency,mild conditions, and benign functional group compatibilitywas reported. Avariety of 3-formylchromone compounds were employed as compatible substrates and this protocol gave the 3-(2-hydroxybenzoyl)-1-aza-anthraquinone derivatives in good to excellent yields without inert gas and expensive transition metal catalysts. Some compounds displayed good anti-proliferative activities.
Synthesis of Chiral cis-Cyclopropane Bearing Indole and Chromone as Potential TNFα Inhibitors
Kanada, Ryutaro,Tanabe, Makoto,Muromoto, Ryuta,Sato, Yukina,Kuwahara, Tomoki,Fukuda, Hayato,Arisawa, Mitsuhiro,Matsuda, Tadashi,Watanabe, Mizuki,Shuto, Satoshi
, p. 7672 - 7682 (2018/07/25)
Conformationally restricted analogues of SPD-304, the first small-molecule TNFα inhibitor, in which two heteroaryl groups, indole and chromone, are connected by chiral methyl- or ethyl-cis-cyclopropane, were designed. Synthesis of these molecules was achieved via Suzuki-Miyaura or Stille coupling reactions with chiral bromomethylenecyclopropane or iodovinyl-cis-cyclopropane as the substrate, both of which were prepared from chiral methylenecyclopropane as a common intermediate, constructing the heteroaryl-methyl or -ethyl-cis-cyclopropane structures as key steps. This study presents an efficient synthesis of a series of chiral cis-cyclopropane conjugates with two heteroaryl groups.
Novel benzofuran-chromone and -coumarin derivatives: Synthesis and biological activity in K562 human leukemia cells
Zwergel, Clemens,Valente, Sergio,Salvato, Angela,Xu, Zhanjie,Talhi, Oualid,Mai, Antonello,Silva, Artur,Altucci, Lucia,Kirsch, Gilbert
supporting information, p. 1571 - 1579 (2013/12/04)
Not widely distributed in nature, aurones, (Z)-2-benzylidene-benzofuran- 3(2H)-ones, are one of the less common and lesser-known representatives of a flavonoid subclass. Nevertheless, they exhibit a strong and broad variety of biological activities. We have combined the benzofuranone part of a classical aurone with either a chromone or a coumarin scaffold which proved to feature interesting biological activities including antimicrobial, antiviral, anticancer, anti-inflammatory and antioxidant properties. Herein we present a series of 26 novel benzofuran derivatives with the first biological results in K562 human leukemia cells showing that compounds 21b, 29b and 29c are able to induce around 24% apoptosis.
2-Hydroxy Ketones, V. --- Preperation of Substituted Chromones
Cascaval, Alexandru
, p. 669 - 672 (2007/10/02)
Various 2-hydroxyacetophenone derivatives react with Vilsmeier reagent according to the Harnisch method to give the substituted chromones 2b-i, which have been identified by elemental analyses and IR and 1H-NMR spectra.
