57806-83-4

Basic information

• Product Name: Ethanone, 1,2-bis[4-(dimethylamino)phenyl]-2-hydroxy-
• CAS NO: 57806-83-4
• Molecular Formula: C18H22N2O2
• Molecular Weight: 298.385
• Mol File: 57806-83-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Ethanone, 1,2-bis[4-(dimethylamino)phenyl]-2-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1,2-bis[4-(dimethylamino)phenyl]-2-hydroxy-(57806-83-4)
• EPA Substance Registry System: Ethanone, 1,2-bis[4-(dimethylamino)phenyl]-2-hydroxy-(57806-83-4)

Safety Data

• Hazardous Substances Data: 57806-83-4(Hazardous Substances Data)

Upstream product

• 100-10-7 4-dimethylamino-benzaldehyde 
• 57806-78-7 p-dimethylamino-1-(dichloromethyl)benzene 
• 68-12-2 N,N-dimethyl-formamide 
• 90-94-8 bis(p-dimethylaminophenyl)methanone 

Relevant articles and documents

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Cytotoxicity of new selenoimine, selenonitrone, and nitrone derivatives against human breast cancer MDA-MB231 cells

A series of new nitrone, selenoimine and selenonitrone derivatives were synthesized. Nitrone and selenonitrone derivatives were synthesized through the condensation reaction between N-mono substitutedhydroxylamine and carbonyl compounds substituted with electron donating groups, such as di(4-methoxy)benzoyl diselenide, 4-(N, N-dimethylamino) benzoyl selenonitrile and 4, 4'-di(N, N- dimethylamino)benzil, afforded a variety of new nitrone and selenonitrone compounds. Selenoimine derivative was synthesized through the condensation reaction between tert-butyl amine and (4-methoxybenzoyl selenonitrile). The yield of synthesized compounds (N1, N2, N3, N4 and N5 were (66, 60, 61, 62 and 45) %, respectively. The structures of the synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR, and mass spectra. Cytotoxicity of selenonitrone (N1) and selenoimine (N3) derivatives against breast cancer cells (MDA-MB231) were evaluated for 24 and 48 h via MTT assay. The IC50 value of compound N1 was 1.714 and 1.897 μM for 24 h and 48 h, respectively. The IC50 value of compound N3 was 1.438 and 2.469 μM for 24 h and 48 h, respectively. The results suggested selenonitrone (N1) and selenoimine (N3) as anti-breast cancer potential lead compound with future merit investigations.

Amine-linked N-heterocyclic carbenes: The importance of an pendant free-amine auxiliary in assisting the catalytic reaction

We have successfully expanded the library of amino-NHCs with varying substituents on the amine group, leading to insight about the instability of NHCs arising from the intermolecular interaction of the dangling amine side-arm. However, the pendant amine plays an important role with respect to the catalytic process, resuscitating the catalytic activity of unsaturated NHC's through a synergistic effect invoked by the secondary amine. This proof of concept allows us to expand the spectrum of catalysis to C-C, as well as C-B bond formation. Copyright