57835-36-6

Basic information

• Product Name: Phenol, 2-bromo-4-octyl-
• CAS NO: 57835-36-6
• Molecular Formula: C14H21BrO
• Molecular Weight: 285.224
• Mol File: 57835-36-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Phenol, 2-bromo-4-octyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-bromo-4-octyl-(57835-36-6)
• EPA Substance Registry System: Phenol, 2-bromo-4-octyl-(57835-36-6)

Safety Data

• Hazardous Substances Data: 57835-36-6(Hazardous Substances Data)

Upstream product

• 1806-26-4 p-Octylphenol 

Relevant articles and documents

Structural analogues of the natural products magnolol and honokiol as potent allosteric potentiators of GABAA receptors

Biphenylic compounds related to the natural products magnolol and 4′-O-methylhonokiol were synthesized, evaluated and optimized as positive allosteric modulators (PAMs) of GABAA receptors. The most efficacious compounds were the magnolol analog 5-ethyl-5′-hexylbiphenyl-2,2′-diol (45) and the honokiol analogs 4′-methoxy-5-propylbiphenyl-2-ol (61), 5-butyl-4′-methoxybiphenyl-2-ol (62) and 5-hexyl-4′-methoxybiphenyl-2-ol (64), which showed a most powerful potentiation of GABA-induced currents (up to 20-fold at a GABA concentration of 3 μM). They were found not to interfere with the allosteric sites occupied by known allosteric modulators, such as benzodiazepines and N-arachidonoylglycerol. These new PAMs will be useful as pharmacological tools and may have therapeutic potential for mono-therapy, or in combination, for example, with GABAA receptor agonists.