5786-26-5

Usage

Uses

Used in Pharmaceutical Industry:
Dibenzo[b,f][1,4]thiazepin-11-amine is used as a reagent for the preparation of other triand tetracyclic heterocycles that have potential central nervous system (CNS) activity. These synthesized compounds may exhibit therapeutic effects on various neurological disorders and conditions, making them valuable in the development of novel pharmaceuticals.
Used in Organic Synthesis:
Dibenzo[b,f][1,4]thiazepin-11-amine is also used as a reactant to synthesize 2-substituted-3-cyano-4-imino-4-H-dibenzo[b,f][1,3]diazino[2,1-d][1,4]thiazepines. These compounds may have anticancer properties, and their synthesis contributes to the ongoing research and development of new cancer treatments.

Upstream product

• 3159-07-7 dibenzo[b,f][1,4]thiazepin-11-one 
• 593-56-6 N-methoxylamine hydrochloride 
• 137-07-5 2-amino-benzenethiol 
• 552-89-6 2-nitro-benzaldehyde 
• 140425-65-6 2-(2-aminophenylthio)-benzonitrile 
• 13745-86-3 11-chloro-dibenzo[b,f][1,4]thiazepine 
• 394-47-8 2-fluorobenzonitrile 

Downstream Products

• 844639-08-3 11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine 

Relevant academic research and scientific papers

Three-Component Synthesis of Dibenzoxazepinamines and Dibenzothiazepinamines under Transition-Metal-Free Conditions

A convenient and efficient strategy for the synthesis of dibenzoxazepinamines and dibenzothiazepinamines has been developed. This three-component approach started from 2-nitrobenzaldehydes, 2-aminophenols, and methoxyammonium chlorides under metal-free conditions. The protocol has the advantages of readily available starting materials, simple and facile conditions, gram-scale synthesis, and broad substrate scope, providing an efficient and practical strategy for the preparation of potential drug-active dibenzoxazepinamines and dibenzothiazepinamines in one pot.

Base-promoted synthesis of dibenzoxazepinamines and quinazolinimines under metal-free conditions

An interesting base-promoted protocol for the synthesis of dibenzo[b,f][1,4]oxazepin-11-amines and quinazolinimines has been developed. Started from commercially available 2-fluorobenzonitriles, 2-aminophenols and 2-aminoethanol, good to excellent yields

A PROCESS FOR THE PREPARATION OF QUETIAPINE

The invention relates to a method for the preparation of 11- (4- [2- (2- hydroxyethoxy) ethyl] -1-piperazinyl] dibenzo [b, f ] -1, 4-thiazepine and pharmaceutically acceptable salts thereof comprising the reaction of 1- [2- (hydroxyethoxy) -ethyl] piperazine with dibenzo [b, f] [1, 4] thiazepin-11-ylamine.

Synthesis of 11-Aminodibenzo[b,f][1,4]thiazepines and Fluoro Derivatives

The reaction of halogenobenzonitriles with 2-aminobenzenethiol is a new route, in a "one-pot" or two-step approach, to 11-aminodibenzo[b,f][1,4]thiazepine and fluoro derivatives.