57877-20-0Relevant academic research and scientific papers
Oxidative Desymmetrization of Isoindolines Realized by tert -Butyl Nitrite (TBN) Initiated Radical sp 3C-H Activation Relay (CHAR)
Sun, Zheng,Shao, Yu,Zhang, Shuwei,Zhang, Yuxian,Yuan, Yu,Jia, Xiaodong
, p. 1663 - 1671 (2021/02/01)
An oxidative desymmetrization of isoindolines was realized by TBN initiated radical sp 3C-H activation relay (CHAR), providing a series of ω-hydroxylactams in high yields. This reaction exhibits broad substrate scope and functional group tolerance, and even N -alkyl iso-indolines can be well tolerated. The mechanistic study shows that the C-H bond oxidation, dioxygen trapping and intramolecular 1,5-H shift might be the key steps to achieve the oxidative desymmetrization.
Some Isoindolo-fused Heterocyclic Systems by Cyclodehydration of N-Arylalkyl-3-hydroxyphthalimidines
Hitchings, Gregory J.,Helliwell, Madeleine,Vernon, John M.
, p. 83 - 87 (2007/10/02)
α-Hydroxy-lactams formed by reduction or Grignard addition to appropriately N-substituted phthalimides (1a-d) undergo acid-catalysed cyclodehydration to derivatives of the isoindolo-fused heterocyclic systems (6)-(10).Ring closures to the naphthalene 2- or 8-position are observed to occur with N-1-naphthylalkyl substituents, the latter proved by an X-ray crystal structure determination of 13b-phenyl-7H-benzisoindoloisoquinolin-9(13H)-one (9b).
