57883-84-8Relevant academic research and scientific papers
Highly efficient synthesis of ureas and carbamates from amides by iodosylbenzene-induced hofmann rearrangement
Liu, Peng,Wang, Zhiming,Hu, Xianming
experimental part, p. 1994 - 2000 (2012/05/05)
A simple and efficient method for the synthesis of 1,3-disubstituted ureas and carbamates from amides by using iodosylbenzene as the oxidant is described. Symmetric and asymmetric ureas and carbamates can be prepared by this procedure in up to 98 % yield. Ureidopeptides can also be prepared in good yield by this method. A simple and efficient method for the synthesis of 1,3-disubstituted ureas and carbamates from amides by using iodosylbenzene as the oxidant is described. By using this method, heterocyclic products can be easily obtained in excellent yield. Ureidopeptides can also be prepared in good yield by this procedure. Copyright
