579-56-6 Usage
Description
Isoxsuprine is an adrenergic receptor modulator that has α-adrenergic receptor (α-AR) antagonist and β-AR agonist properties. It induces vasodilation of isolated equine common digital artery strips precontracted with norepinephrine, indicating an α-AR effect, and induces relaxation of isolated fowl cecum, an effect that can be blocked by the β-AR antagonist propranolol (Item Nos. 23349 | 17291). Isoxsuprine has antinociceptive effects in an acetic acid writhing test in mice. It also inhibits oxytocin-induced contractions in isolated rat uterus (IC50 = 9.15 μM). It delays labor onset in rats by 31.63 hours when administered at a dose of 10 mg/kg per day on days 13 to 21 of gestation but increases heart rate with increasing concentration.
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 579-56-6 differently. You can refer to the following data:
1. As a vasilodator drug, Isoxsuprine Hydrochloride is used in veterinary medicine for the treatment of navicular syndrome and laminitis in horses. Isoxsuprine Hydrochloride has been shown to be a β-adrenoreceptor antagonist with β-adrenoreceptor agonistic properties, with both characteristics contributing to vasodilation and uterine relaxation. Studies suggest that Isoxsuprine Hydrochloride may be useful as a as a tocolytic agent in the treatment of preterm labour.
2. vasodilator
3. antiepileptic
4. It is prescribed for the symptomatic relief of cerebrovascular insufficiency and improvement of circulation
Therapeutic Function
Vasodilator
Veterinary Drugs and Treatments
Isoxsuprine is used in veterinary medicine principally for the treatment
of navicular
disease in horses; however, recent studies have
shown disappointing efficacy when used orally. It has been used in
humans for the treatment of cerebral vascular insufficiency, dysmenorrhea,
and premature labor, but efficacies are unproven for
these indications.
There has been an anecdotal report of isoxsuprine being helpful
for treating dogs with a Raynaud’s-like syndrome (periodic digital
cyanosis, onychogryphosis) (Carlotti 2002).
in vivo
animal stroke model, 1 mg/kg isoxsuprine was administered after a 90-minute occlusion of the right middle cerebral artery by iv injection at reperfusion. total infarct volume in isoxsuprine-treated group was 137±18 mm3 compared to 279±25 mm3 in control group [2].
references
1. r. s. ekert and c. g. macallister. isoxsuprine hydrochloride in the horse: a review. j. vet. pharmacol. ther. 2002, 25(2), 81-87 2. hill jw, thompson jf, carter mb. identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. plos one. 2014 may 7; 9(5):e96761
Check Digit Verification of cas no
The CAS Registry Mumber 579-56-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,7 and 9 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 579-56:
(5*5)+(4*7)+(3*9)+(2*5)+(1*6)=96
96 % 10 = 6
So 579-56-6 is a valid CAS Registry Number.
InChI:InChI=1/C18H23NO3.ClH/c1-13(12-22-17-6-4-3-5-7-17)19-14(2)18(21)15-8-10-16(20)11-9-15;/h3-11,13-14,18-21H,12H2,1-2H3;1H
579-56-6Relevant articles and documents
Method of treating navicular disease in horses
-
, (2008/06/13)
A method of treating navicular disease in horses comprising the administration of Isoxsuprine over an extended period and an injectable paste composition including isoxsuprine hydrochloride and pharmaceutically acceptable carriers and flavorants for use in said method.