579-56-6 Usage
Uses
Used in Veterinary Medicine:
Isoxsuprine Hydrochloride is used as a vasodilator drug for the treatment of navicular syndrome and laminitis in horses. Its α-AR antagonist and β-AR agonist properties contribute to vasodilation and uterine relaxation, providing relief and treatment for these conditions in equine patients.
Used in Human Medicine Tocolytic Agent:
Isoxsuprine Hydrochloride is used as a tocolytic agent in the treatment of preterm labor. Its ability to induce uterine relaxation helps delay the onset of labor, providing more time for the development of the fetus and improving the chances of a healthy birth.
Used in Human Medicine Cerebrovascular Insufficiency:
Isoxsuprine Hydrochloride is used as a vasodilator for the symptomatic relief of cerebrovascular insufficiency. By improving blood circulation in the brain, it helps alleviate symptoms associated with this condition.
Used in Human Medicine Antiepileptic:
Isoxsuprine Hydrochloride is used as an antiepileptic medication, potentially providing relief from seizures and improving the quality of life for patients suffering from epilepsy.
Therapeutic Function
Vasodilator
Veterinary Drugs and Treatments
Isoxsuprine is used in veterinary medicine principally for the treatment
of navicular
disease in horses; however, recent studies have
shown disappointing efficacy when used orally. It has been used in
humans for the treatment of cerebral vascular insufficiency, dysmenorrhea,
and premature labor, but efficacies are unproven for
these indications.
There has been an anecdotal report of isoxsuprine being helpful
for treating dogs with a Raynaud’s-like syndrome (periodic digital
cyanosis, onychogryphosis) (Carlotti 2002).
in vivo
animal stroke model, 1 mg/kg isoxsuprine was administered after a 90-minute occlusion of the right middle cerebral artery by iv injection at reperfusion. total infarct volume in isoxsuprine-treated group was 137±18 mm3 compared to 279±25 mm3 in control group [2].
references
1. r. s. ekert and c. g. macallister. isoxsuprine hydrochloride in the horse: a review. j. vet. pharmacol. ther. 2002, 25(2), 81-87 2. hill jw, thompson jf, carter mb. identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. plos one. 2014 may 7; 9(5):e96761
Check Digit Verification of cas no
The CAS Registry Mumber 579-56-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,7 and 9 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 579-56:
(5*5)+(4*7)+(3*9)+(2*5)+(1*6)=96
96 % 10 = 6
So 579-56-6 is a valid CAS Registry Number.
InChI:InChI=1/C18H23NO3.ClH/c1-13(12-22-17-6-4-3-5-7-17)19-14(2)18(21)15-8-10-16(20)11-9-15;/h3-11,13-14,18-21H,12H2,1-2H3;1H
579-56-6Relevant academic research and scientific papers
Method of treating navicular disease in horses
-
, (2008/06/13)
A method of treating navicular disease in horses comprising the administration of Isoxsuprine over an extended period and an injectable paste composition including isoxsuprine hydrochloride and pharmaceutically acceptable carriers and flavorants for use in said method.
