57901-65-2Relevant academic research and scientific papers
Synthesis and anti-HCV activity of N9,5′-cyclo-3-(β- D-ribofuranosyl)-8-azapurin-2-one derivatives
Hassan, Abdalla E. A.,Wang, Peiyuan,McBrayer, Tamara,Tharnish, Philip,Stuyver, Lieven,Otto, Michael J.,Watanabe, Kyoichi A.,Schinazi, Raymond F.
, p. 1531 - 1542 (2007/10/03)
□ A number of 1- or 6-substituted N9,5′-cyclo-3- (β-D-ribofuranosyl)-8-azapurin-2-one derivatives were synthesized in multi-step reactions. Their anti-hepatitis C virus activities were evaluated and some structure-activity relationship is discussed. Copyright Taylor & Francis Group, LLC.
Synthesis and anti-hepatitis C virus activity of nucleoside derivatives of N3,5′-anhydro-4-(β-D ribofuranosyl)-8-azapurin-2-ones
Hassan, Abdalla E. A.,Wang, Peiyuan,McBrayer, Tamara R.,Tharnish, Phillip M.,Stuyver, Lieven J.,Schinazi, Raymond F.,Otto, Michael J.,Watanabe, Kyoichi A.
, p. 961 - 964 (2007/10/03)
A series of N3,5′-Anhydro-4-(β-D-ribofuranosyl)-8- azapurin-2-ones were prepared in multistep reactions from uridine as potential anti-hepatitis C virus (HCV) agents. The synthetic details as well as biological evaluations are discussed. Copyright Taylor & Francis, Inc.
