57902-11-1Relevant academic research and scientific papers
Reactions of 1,4-dinitroimidazoles with hydrazines
Suwinski, Jerzy,Szczepankiewicz, Wojciech,Holt, Elizabeth M.
, p. 14905 - 14916 (2007/10/03)
Reaction of 2-methyl-1,4-dinitroimidazole with hydrazine results in expansion of the imidazole ring and formation of the 1.2.4-triazine derivative. Reaction of 1,4-dinitroimidazole with N-aminomorpholine yields 1-(N-morpholino)-4-nitroimidazole, by degenerative transformation of the imidazole ring. Treatment of 1,4-dinitroimidazoles with t-butoxycarbonylhydrazine results in the break down of the imidazole ring and formation of glyoxal dihydrazone derivatives. Structures of representative heterocyclic products were determined by X-ray analysis.
SYNTHESIS OF 4-METHOXYPHENOXYACETIC AND 3,4,5-TRIMETHOXYPHENOXYACETIC ACID AMIDES AND HYDRAZIDES AS POTENTIAL NEUROTROPIC AND CARDIOVASCULAR AGENTS
Valenta, Vladimir,Holubek, Jiri,Svatek, Emil,Protiva, Miroslav
, p. 3013 - 3023 (2007/10/02)
4-Methoxyphenoxyacetyl chloride, 3,4,5-trimethoxyphenoxyacetic acid and its methyl ester were reacted with 2-phenylethylamine, 1-benzylpiperazine, 1-(2-phenylethyl)piperazine, 1-(1-phenyl-2-propyl)piperazine, isopropylhydrazine, 1-aminopiperidine, and 4-aminomorpholine and afforded the amides and hydrazides Iab-IVab and Vb-VIIIb. 1-Amino-4-methylpiperazine and 1-amino-4-phenylpiperazine were transformed to the hydrazones XV and XVI, and to the quaternary salts XVII and XVIII.Pharmacological screening showed indications of thymoleptic acitivity with compounds Ia-IIIa, anorectic effect with IIa and IIIb, antiarrhytmic activity with IIIa, XVII, and XVIII, and myorelaxant effect with XVII and XVIII.Antimicrobial and anthelmintic effects were also noted.
