57937-60-7

Basic information

• Product Name: 2-CHLOROMETHYLIMIDAZO[1,2-A]PYRAZINE
• Synonyms: 2-CHLOROMETHYLIMIDAZO[1,2-A]PYRAZINE
• CAS NO: 57937-60-7
• Molecular Formula: C₇H₆ClN₃
• Molecular Weight: 167.6
• Mol File: 57937-60-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 110℃ (DEC.)
• Appearance: /
• Density: 1.42
• PKA: 3.38±0.30(Predicted)
• CAS DataBase Reference: 2-CHLOROMETHYLIMIDAZO[1,2-A]PYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROMETHYLIMIDAZO[1,2-A]PYRAZINE(57937-60-7)
• EPA Substance Registry System: 2-CHLOROMETHYLIMIDAZO[1,2-A]PYRAZINE(57937-60-7)

Safety Data

• Hazardous Substances Data: 57937-60-7(Hazardous Substances Data)

Usage

General Description

2-Chloromethylimidazo[1,2-a]pyrazine is a chemical compound that belongs to the class of imidazo[1,2-a]pyrazines, which are heterocyclic aromatic compounds. It is also known as CMIP and has the molecular formula C6H5ClN4. 2-CHLOROMETHYLIMIDAZO[1,2-A]PYRAZINE is commonly used in the pharmaceutical and agrochemical industries, as it serves as a versatile building block for the synthesis of various bioactive molecules and agricultural chemicals. It has been found to exhibit antitumor and antimicrobial activities, making it a valuable intermediate in drug discovery and development. Additionally, it is recognized for its role as a potential mutagenic compound when exposed to certain environmental conditions or chemical reactions. Overall, 2-chloromethylimidazo[1,2-a]pyrazine is an important chemical with diverse applications in various fields.

Upstream product

• 5049-61-6 2-Aminopyrazine 
• 534-07-6 1,3-Dichloroacetone 

Downstream Products

• 87597-28-2 2-(hydroxymethyl)imidazo[1,2-a]pyrazine 

Relevant articles and documents

IMIDAZOPYRIDINES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS

A compound satisfying formula I, a prodrug, N-oxide, addition salt, quaternary amine, metal complex, or a stereochemically isomeric form thereof; compositions contain these compounds as active ingredient and processes for preparing these compounds and compositions.

Synthesis of imidazo[1,2-a]pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties

A series of imidazo[1,2-a]pyrazine derivatives was synthesized by condensation of α-halogenocarbonyl compounds and aminopyrazines. Various compounds resulted from competitive reactions or reagent isomerization and demonstrated in vitro uterine-relaxing and in vivo antibronchospastic activities. On isolated atria, 5-bromoimidazo[1,2-a]pyrazine showed positive chronotropic and inotropic properties; the latter was associated with an increase in the cyclic AMP tissue concentration. Potentiation of the isoproterenol positive inotropic effect of 5-bromoimidazo[1,2-a]pyrazine and the lack of blockade of the 5-bromoimidazo[1,2-a]pyrazine positive inotropic effect by propranolol suggested phosphodiesterase-inhibiting properties.