57946-55-1

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-AMINO-PHENYL)-2-BROMO-ETHANONE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(3-AMINO-PHENYL)-2-BROMO-ETHANONE is utilized as an intermediate in the production of agrochemicals. Its properties make it suitable for the creation of compounds used in agriculture to protect crops and enhance yields.
Used in Organic Synthesis:
1-(3-AMINO-PHENYL)-2-BROMO-ETHANONE is used as a building block in organic synthesis for creating other chemical compounds with specific properties. Its reactivity and structure make it a valuable component in the synthesis of specialized organic compounds.
Used in Research Applications:
1-(3-AMINO-PHENYL)-2-BROMO-ETHANONE is also used in research settings to explore its properties and potential applications. Its unique structure and reactivity make it an interesting subject for scientific study and experimentation.
Safety Note:
Due to its potential hazards, 1-(3-AMINO-PHENYL)-2-BROMO-ETHANONE requires careful handling and storage. It should be used in a well-ventilated area, and appropriate personal protective equipment should be worn to ensure safety.

Upstream product

• 99-03-6 1-(3-aminophenyl)ethanone 

Downstream Products

• 1116151-81-5 C₂₀H₁₈N₄OS 
• 1116151-85-9 C₁₉H₁₆N₄OS 
• 432004-76-7 3-(quinoxalin-2-yl)benzenamine 
• 30095-56-8 1-(3-Acetylaminophenyl)-2-bromoethanone 
• 1432790-64-1 C₁₆H₁₅N₅O₃S₂ 
• 1414627-39-6 3-(2-(2-chloro-5-nitrophenyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)aniline 
• 1414627-03-4 3-(2-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)aniline 
• 1335016-19-7 3-(2-cyclopropylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)aniline 
• 27573-46-2 N-[3-(2-Bromo-acetyl)-phenyl]-C,C,C-trifluoro-methanesulfonamide 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis

Abstract The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel present in the membrane of epithelial cells. Mutations affecting the CFTR gene cause cystic fibrosis (CF), a multi-organ severe disease. The most common CF mutation, F508del, impairs the processing and activity (gating) of CFTR protein. Other mutations, like G551D, only cause a gating defect. Processing and gating defects can be targeted by small molecules called generically correctors and potentiators, respectively. Aminoarylthiazoles (AATs) represent an interesting class of compounds that includes molecules with dual activity, as correctors and potentiators. With the aim to improve the activity profile of AATs, we have now designed and synthesized a library of novel compounds in order to establish an initial SAR that may provide indications about the chemical groups that are beneficial or detrimental for rescue activity. The new compounds were tested as correctors and potentiators in CFBE41o-expressing F508del-CFTR using a functional assay. A dual active compound, AAT-4a, characterized by improved efficacy and marked synergy when combined with the corrector VX-809 has been identified. Moreover, by computational methods, a possible binding site for AATs in nucleotide binding domain NBD1 has been detected. These results will direct the synthesis of new analogues with possibly improved activity.