579461-38-4Relevant academic research and scientific papers
BICYCLIC PYRIDONE LACTAMS AND METHODS OF USE THEREOF
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Page/Page column 68; 69, (2018/05/15)
The invention provides novel compounds having the general formula (I) wherein R1, X, Zlto Z5, L, n, the A ring, and the B ring, are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.Compounds (I) act as inhibitors of RIP1 kinase.
INHIBITORS OF RIP1 KINASE AND METHODS OF USE THEREOF
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Paragraph 0357; 0358, (2018/07/04)
The invention provides novel compounds having RIP1 kinase inhibitory activity, pharmaceutical compositions including the compounds and methods of using the compounds.
Photoinduced cleavage of DNA by bromofluoroacetophenone-pyrrolecarboxamide conjugates
Wender, Paul A.,Jeon, Raok
, p. 1763 - 1766 (2007/10/03)
Bromofluoroacetophenone derivatives which produce fluorine substituted phenyl radicals that cleave DNA upon excitation were investigated as a novel photonuclease. Pyrrolecarboxamide-conjugated bromofluoroacetophenones; 4′-bromo-2′-fluoroacetophenone and 2′-bromo-4′-fluoroacetophenone were synthesized and their DNA cleaving activities and sequence selectivities were determined. Bromofluoroacetophenone-pyrrolecarboxamide conjugates were found to be effective DNA cleaving agents upon irradiation in concentration dependent manner based on plasma relaxation assay. The DNA cleaving activities of 2′-bromo-4′-fluoroacetophenone derivatives were larger than those of 4′-bromo-2′-fluoroacetophenone derivatives.
