579477-75-1

Upstream product

• 473537-79-0 tert-butyl (2-amino-5-methyl-4-(trifluoromethyl)phenyl)carbamate 
• 579475-06-2 3-oxo-3-(3-pyrazin-2-yl-phenyl)-propionic acid tert-butyl ester 

Downstream Products

• 579473-92-0 7-methyl-4-(3-pyrazin-2-yl-phenyl)-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one 

Relevant academic research and scientific papers

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. in vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists

This study completes a series of papers devoted to the characterization of the non-competitive mGluR2/3 antagonist properties of 1,3-dihydro-benzo[b][1,4] diazepin-2-one derivatives with particular emphasis on derivatizations compatible with brain penetra

Dihydro-benzo[b][1,4]diazepin-2-one derivatives

This invention relates to dihydro-benzo[b][1,4]diazepin-2-one derivatives of the formula wherein R1, R2, X and Y are as defined in the specification and R3 is a six-membered aromatic heterocycle containing 1 to 3 nitrogen atoms or a pyridine-N-oxide as further defined in the specification. The invention further relates to medicaments containing these compounds, a process for their preparation as well as their use for preparation of medicaments for the treatment or prevention of acute and/or chronic neurological disorders.