579481-91-7Relevant academic research and scientific papers
Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. in vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists
Woltering, Thomas J.,Wichmann, Jürgen,Goetschi, Erwin,Knoflach, Frédéric,Ballard, Theresa M.,Huwyler, J?rg,Gatti, Silvia
scheme or table, p. 6969 - 6974 (2011/02/22)
This study completes a series of papers devoted to the characterization of the non-competitive mGluR2/3 antagonist properties of 1,3-dihydro-benzo[b][1,4] diazepin-2-one derivatives with particular emphasis on derivatizations compatible with brain penetra
COMBINATION OF MGLUR2 ANTAGONIST AND ACHE INHIBITOR FOR TREATMENT OF ACUTE AND/OR CHRONIC NEUROLOGICAL DISORDERS
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Page/Page column 46, (2008/06/13)
The present invention relates to a method of treatment or prevention of acute and/or chronic neurological disorders, to a pharmaceutical composition comprising an inhibitor of acetylcholinesterase (AChE inhibitor) and a metabotropic Glutamate receptor 2 antagonist (mGluR2 antagonist), to the use of an AChE inhibitor and a mGluR2 antagonist in the preparation of a medicament, and. to kits comprising an AChE inhibitor and a mGluR2 antagonist.
Dihydro-benzo[b][1,4]diazepin-2-one derivatives
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, (2008/06/13)
This invention relates to dihydro-benzo[b][1,4]diazepin-2-one derivatives of the formula wherein R1, R2, X and Y are as defined in the specification and R3 is a six-membered aromatic heterocycle containing 1 to 3 nitrogen atoms or a pyridine-N-oxide as further defined in the specification. The invention further relates to medicaments containing these compounds, a process for their preparation as well as their use for preparation of medicaments for the treatment or prevention of acute and/or chronic neurological disorders.
