579486-74-1

Basic information

• Product Name: 4H-1,2,3-Triazolo[4,5-c]pyridin-4-one, 6-[[(3,4-dichlorophenyl)methyl]amino]-3,5-dihydro-3-(5-methoxypentyl)-
• CAS NO: 579486-74-1
• Molecular Formula: C18H21Cl2N5O2
• Molecular Weight: 410.303
• Mol File: 579486-74-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4H-1,2,3-Triazolo[4,5-c]pyridin-4-one, 6-[[(3,4-dichlorophenyl)methyl]amino]-3,5-dihydro-3-(5-methoxypentyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1,2,3-Triazolo[4,5-c]pyridin-4-one, 6-[[(3,4-dichlorophenyl)methyl]amino]-3,5-dihydro-3-(5-methoxypentyl)-(579486-74-1)
• EPA Substance Registry System: 4H-1,2,3-Triazolo[4,5-c]pyridin-4-one, 6-[[(3,4-dichlorophenyl)methyl]amino]-3,5-dihydro-3-(5-methoxypentyl)-(579486-74-1)

Safety Data

• Hazardous Substances Data: 579486-74-1(Hazardous Substances Data)

Upstream product

• 501358-54-9 4,6-dichloro-3H-[1,2,3]triazolo[4,5-c]pyridine 
• 579486-73-0 2-methoxy-3-(5-methoxypentyl)-7-chlorotriazolo[4,5-c]pyridine 
• 102-49-8 3,4-dichlorobenzyl amine 

Relevant articles and documents

7-Alkyl-N2-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity

Several 2-anilino- and 2-benzylamino-3-deaza-6-oxopurines [3-deazaguanines] and selected 8-methyl and 8-aza analogs have been synthesized. 7-Substituted N2-(3-ethyl-4-methylphenyl)-3-deazaguanines were potent and selective inhibitors of Gram+ bacterial DNA polymerase (pol) IIIC, and 7-substituted N2-(3,4-dichlorobenzyl)-3-deazaguanines were potent inhibitors of both pol IIIC and pol IIIE from Gram+ bacteria, but weakly inhibited pol IIIE from Gram- bacteria. Potent enzyme inhibitors in both classes inhibited the growth of Gram+ bacteria (MICs 2.5-10 μg/ml), and were inactive against the Gram- organism Escherichia coli. Several derivatives had moderate protective activity in Staphylococcus aureus-infected mice.