57950-03-5Relevant academic research and scientific papers
COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISEASES OR INJURY
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Paragraph 00212, (2014/05/24)
Provided are compounds for the treatment of neurological diseases or injuries, including neurodegenerative diseases, stroke, trauma, epilepsy, acute and chronic kidney injuries, diabetes mellitus, and/or seizures. In some embodiments, derivatives of vitamin K are provided.
Structure-activity relationship study of vitamin K derivatives yields highly potent neuroprotective agents
Josey, Benjamin J.,Inks, Elizabeth S.,Wen, Xuejun,Chou, C. James
, p. 1007 - 1022 (2013/03/28)
Historically known for its role in blood coagulation and bone formation, vitamin K (VK) has begun to emerge as an important nutrient for brain function. While VK involvement in the brain has not been fully explored, it is well-known that oxidative stress plays a critical role in neurodegenerative diseases. It was recently reported that VK protects neurons and oligodendrocytes from oxidative injury and rescues Drosophila from mitochondrial defects associated with Parkinson's disease. In this study, we take a chemical approach to define the optimal and minimum pharmacophore responsible for the neuroprotective effects of VK. In doing so, we have developed a series of potent VK analogues with favorable drug characteristics that provide full protection at nanomolar concentrations in a well-defined model of neuronal oxidative stress. Additionally, we have characterized key cellular responses and biomarkers consistent with the compounds' ability to rescue cells from oxidative stress induced cell death.
Synthesis and screening of substituted 1,4-naphthoquinones (NPQs) as antifilarial agents
Mathew, Nisha,Karunan, Twinkle,Srinivasan, Lakshmy,Muthuswamy, Kalyanasundaram
experimental part, p. 188 - 196 (2011/10/30)
Eleven amino-substituted 1,4-naphthoquinones were synthesized via the reaction of 1,4-naphthoquinone with different primary and secondary mono- and diamines in the presence of dichloromethane ethanol (1:2) solvent at room temperature. All compounds were p
A general procedure for the efficient synthesis of (alkylamino)naphthoquinones
Couladouros, Elias A.,Plyta, Zoi F.,Papageorgiou, Vassilios P.
, p. 3031 - 3033 (2007/10/03)
Alkylamino derivatives of naphthazarine, juglone, and naphthoquinone have been synthesized via their corresponding bromo-analogues, in high yields, especially in the case of naphthazarins.
