579525-48-7

Basic information

• Product Name: L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3,5-dimethyl-, methyl ester
• CAS NO: 579525-48-7
• Molecular Formula: C17H25NO5
• Molecular Weight: 323.389
• Mol File: 579525-48-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3,5-dimethyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3,5-dimethyl-, methyl ester(579525-48-7)
• EPA Substance Registry System: L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3,5-dimethyl-, methyl ester(579525-48-7)

Safety Data

• Hazardous Substances Data: 579525-48-7(Hazardous Substances Data)

Upstream product

• 594-27-4 tetramethylstannane 
• 128781-80-6 (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-3,5-diiodophenyl)propanoate 
• 1204139-74-1 (2S)-(N-tert-butoxycarbonylamino)-3-(2'-benzyloxy-1',3'-dimethylphen-5'-yl)-propionic acid methyl ester 

Relevant articles and documents

ANTI-MALIGNANT TUMOR AGENT COMPOSITION

To provide a satisfactory anticancer agent composition suppressing the growth of cancer (malignant tumor) reliably and hardly causing side effects, the present invention is directed to an anticancer agent composition including the following agents as active ingredient; a LAT1 inhibitor, and one or more agents selected from the group consisting of an alkylating agent, a platinum-based antineoplastic agent, an anti-metabolite, a topoisomerase inhibitor, an anti-microtubule polymerizing agent, a hormonal agent, an anti-microtubule depolymerizing agent, an anticancer antibiotic, and a molecular targeted agent.

AROMATIC AMINO ACID DERIVATIVES AND MEDICINAL COMPOSITIONS

An aromatic amino acid derivative represented by the formula ( I ) or its pharmacologically acceptable salt: wherein,R1 is a hydrogen atom or an amino-protecting group,R2 is a halogen atom or an alkyl, aralkyl or aryl group,R3 is 1○ a hydrogen atom, 2○ an aroylamino group, 3○ a phenyl group substituted with lower alkyl, phenyl, phenoxy, etc. 4○ a naphthyl or tetrahydronaphthyl group optionally substituted with hydroxy, lower alkoxy or di(lower)alkylamino, 5○ an unsaturated mono-cyclic heterocyclic group containing N, O and/or S substituted with lower alkyl, phenyl, naphthyl or tetrahydroquinolyl, 6○ an unsaturated or partially saturated condensed heterocyclic group containing N, O and/or S, optionally substituted with oxo, carboxy, amino, lower alkyl, etc.; X is a halogen atom, an alkyl group or an alkoxy group; Y is oxygen atom or nitrogen atom; 1 is 0 or 1; m is 0, 1 or 2; n is an integer of 0-5. This compound can inhibit a transporter (LAT1) of essential amino acid which is one of main nutrition for cancer cells and accordingly cause drain of the essential amino acid on the cancer cells and finally can prohibit the multiplication of cancer cells.