57960-31-3

Basic information

• Product Name: ACEQUINOCYL-HYDROXY
• Synonyms: ACEQUINOCYL-HYDROXY;ACEQUINOCYL-HYDROXY STANDARD
• CAS NO: 57960-31-3
• Molecular Formula: C₂₂H₃₀O₃
• Molecular Weight: 342.47
• Mol File: 57960-31-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 94～98℃
• Boiling Point: 475.9°C at 760 mmHg
• Flash Point: 255.7°C
• Appearance: /
• Density: 1.076g/cm³
• Vapor Pressure: 7.28E-10mmHg at 25°C
• Refractive Index: 1.542
• PKA: 5.10±0.10(Predicted)
• CAS DataBase Reference: ACEQUINOCYL-HYDROXY(CAS DataBase Reference)
• NIST Chemistry Reference: ACEQUINOCYL-HYDROXY(57960-31-3)
• EPA Substance Registry System: ACEQUINOCYL-HYDROXY(57960-31-3)

Safety Data

• Hazardous Substances Data: 57960-31-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C22H30O3/c1-2-3-4-5-6-7-8-9-10-11-16-19-20(23)17-14-12-13-15-18(17)21(24)22(19)25/h12-15,25H,2-11,16H2,1H3

Upstream product

• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 56038-98-3 dilauroyl peroxide 
• 64955-09-5 2-Dodecyl-[1]naphthol 
• 64955-08-4 2-n-dodecyl-1-naphthol-4-sulfonic acid 
• 112-53-8 1-dodecyl alcohol 
• 64-17-5 ethanol 
• 64955-12-0 3-chloro-2-n-dodecyl-1,4-naphthoquinone 
• 130-15-4 [1,4]naphthoquinone 
• 1785-67-7 1,2,4-triacetyloxynaphthalene 

Downstream Products

• 57960-19-7 acequinocyl 
• 125110-78-3 2-(1-methylaminododecyl)-3-hydroxy-1,4-naphthoquinone 

Relevant articles and documents

Naphthoquinone compounds and preparation and acaricidal and bactericidal application thereof

The invention relates to naphthoquinone compounds as well as a preparation and acaricidal and bactericidal application thereof, and relates to 15 kinds of 2, 3-substituted naphthoquinone derivatives as well as a preparation method and acaricidal and bactericidal application thereof. The preparation method comprises the following steps: carrying out addition reaction on 2-hydroxy-1, 4 naphthoquinone with different aldehydes to obtain compounds 1-6, and carrying out condensation reaction with different acyl chlorides or sulfonyl chlorides under the catalysis of alkali to obtain compounds 7-15. The compounds can be used as acaricides for preventing and treating crop mites, and can also be used as bactericides for preventing and treating botrytis cinerea, valsa mali, fusarium oxysporum and gaeumannomyces graminis.

Synthesis and biological evaluation of lipophilic 1,4-naphthoquinone derivatives against human cancer cell lines

To examine the effect of hydrophobicity on the anticancer activity of 1,4-naphthoquinone derivatives, a series of compounds bearing a 2-O-alkyl-, 3-C-alkyl- or 2/3-N-morpholinoalkyl group were synthesized and evaluated for their anticancer activity against five human cancer cell lines in vitro. The cytotoxicity of these derivatives was assayed against HT-29, SW480, HepG2, MCF-7 and HL-60 cells by the MTT assay. Among them, 2-hydroxy-3-farnesyl-1,4-naphthoquinone (11a) was found to be the most cytotoxic against these cell lines. Our results showed that the effectiveness of compound 11a may be attributed to its suppression of the survival of HT-29. Secondly, in the Hoechst 33258 staining test, compound 11a-treated cells exhibited nuclear condensation typical of apoptosis. Additionally, cell cycle analysis by flow cytometry indicated that compound 11a arrested HT-29 cells in the S phase. Furthermore, cell death detected by Annexin V-FITC/propidium iodide staining showed that compound 11a efficiently induced apoptosis of HT-29 in a concentration-dependent manner. Taken together, compound 11a effectively inhibits colon cancer cell proliferation and may be a potent anticancer agent.

Miticidal ethers

Naphthoquinone ethers are useful as miticides having improved knockdown characteristics.