57962-55-7Relevant academic research and scientific papers
De novodesign and synthesis of dipyridopurinone derivatives as visible-light photocatalysts in productive guanylation reactions
Gao, Wenjing,Ma, Nana,Wan, Yameng,Wu, Hao,Zhang, Guisheng,Zhang, Zhiguo,Zhao, Jie
, p. 15988 - 15997 (2021/12/30)
Described here is thede novodesign and synthesis of a series of 6H-dipyrido[1,2-e:2′,1′-i]purin-6-ones (DPs) as a new class of visible-light photoredox catalysts (PCs). The synthesizedDP1-5showed theirλAbs(max)values in 433-477 nm, excited state redox potentials in 1.15-0.69 eV and ?1.41 to ?1.77 eV (vs.SCE), respectively. As a representative,DP4enables the productive guanylation of various amines, including 1°, 2°, and 3°-alkyl primary amines, secondary amines, aryl and heteroaryl amines, amino-nitrile, amino acids and peptides as well as propynylamines and α-amino esters giving diversities in biologically important guanidines and cyclic guanidines. The photocatalytic efficacy ofDP4in the guanylation overmatched commonly used Ir and Ru polypyridyl complexes, and some organic PCs. Other salient merits of this method include broad substrate scope and functional group tolerance, gram-scale synthesis, and versatile late-stage derivatizations that led to a derivative81exhibiting 60-fold better anticancer activity against Ramos cells with the IC50of 0.086 μM than that of clinical drug ibrutinib (5.1 μM).
A multi-substituted 2 - amino imidazole compound preparation method
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Paragraph 0058-0060, (2018/01/05)
The invention provides a preparation method for a polysubstituted 2-aminooimidazole compound. The compound is described in a formula (III). The preparation method comprises the following steps: subjecting propargylamine as shown in a formula (I) and carbodiimide as shown in a formula (II) to cyclization reaction in an aprotic polar solvent under the action of an alkaline matter and a condition of 25 to 125 DEG C temperature, then carrying out TLC trace monitoring until the reaction is completed, and post-treating obtained reaction liquid so as to obtain the polysubstituted 2-aminooimidazole compound. The preparation method for the polysubstituted 2-aminooimidazole compound provided by the invention has the following advantages: reaction raw materials are cheap and easily available; a noble metal catalyst is not needed in reaction process; reaction conditions are mild; the method in the invention is green and environmentally friendly and has high atom economy.
Amino-2 imidazoles
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, (2008/06/13)
Aminoimidazoles of the formula SPC1 Wherein R1 is optionally substituted phenyl, R4 is hydrogen or alkyl, R 5 is hydrogen or methyl and R2 and R3 form, together with the nitrogen atom to which they ar
