57968-49-7

Basic information

• Product Name: (5S,6S)-5,6-dihydroxy-5-methyldihydropyrimidine-2,4(1H,3H)-dione
• Synonyms: 2,4(1H,3H)-Pyrimidinedione, dihydro-5,6-dihydroxy-5-methyl-, (5S-trans)-
• CAS NO: 57968-49-7
• Molecular Formula: C₅H₈N₂O₄
• Molecular Weight: 160.128
• Mol File: 57968-49-7.mol
• Article Data: 4

Chemical Properties

• Density: 1.541g/cm³
• Refractive Index: 1.551
• CAS DataBase Reference: (5S,6S)-5,6-dihydroxy-5-methyldihydropyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (5S,6S)-5,6-dihydroxy-5-methyldihydropyrimidine-2,4(1H,3H)-dione(57968-49-7)
• EPA Substance Registry System: (5S,6S)-5,6-dihydroxy-5-methyldihydropyrimidine-2,4(1H,3H)-dione(57968-49-7)

Safety Data

• Hazardous Substances Data: 57968-49-7(Hazardous Substances Data)

Upstream product

• 696-04-8 5,6-dihydrothymine 
• 65-71-4 thymin 
• 70-54-2 2,6-diaminocaproic acid 
• 50-89-5 thymidine 

Downstream Products

• 2417-22-3 5-methylbarbituric acid 
• 65-71-4 thymin 
• 13514-92-6 6-Hydroxydihydrothymine 
• 696-04-8 5,6-dihydrothymine 
• 33599-50-7 cis-6-hydroperoxy-5-hydroxy-5,6-dihydrothymine 

Relevant articles and documents

Hydroxyl radical-induced cross-linking of thymine and lysine: Identification of the primary structure and mechanism

Hydroxyl radical-induced formation of a cross-link of thymine (Thy) and lysine (Lys) in the γ-radiolysis of N2O-saturated aqueous solution was studied. A Thy-Lys cross-link (I) of the formal structure that OH radical and 4-carbon-centered Lys radical added respectively to C(5) and C(6) positions of Thy was isolated by a preparative HPLC and identified by a FAB-HRMS. The primary cross-link I was dehydrated by treatment with HCl at 120°C to yield the secondary structure (II) possessing a C(5)-C(6) double bond in the Thy moiety: the latter structure II was reported previously (Dizdaroglu, M.; Gajewski, E. Cancer Res. 1989, 49, 3463-3467). A pulse radiolysis study with a redox titration method indicated that 4-carbon centered Lys radical intermediate was of neutral redox reactivity in contrast to reducing reactivity of 5-hydroxy-5,6-dihydrothymin-6-yl radical intermediate. The cross-link I could be formed by a conventional radical recombination mechanism, but not by an ionic recombination mechanism involving a redox reaction between the radical intermediates.

Radiation-Induced Degradation of Purine and Pyrimidine 2'-Deoxyribonucleosides in Aqueous KBr Solutions

Steady-state γ-radiolysis of 5E-4 M pyrimidine and purine 2'-deoxyribonucleosides in aqueous solutions saturated with N2, N2O and O2, respectively, have been carried out in the presence of 0.1 M KBr.The main final degradation products have been isolated and characterised by various spectroscopic measurements including 1H and 13C NMR, UV, C.D. and mass spectrometry.The radiation-induced decomposition of thymidine is mostly accounted for by an ionic mechanism involving Br2, the decay product of Br2, as the reactive oxidising specie.On the other hand the degradation of the purine ring of 2'-deoxyadenosine and 2'-deoxyguanosine may be accounted for by the action of Br2 or Br3. - Keywords: 2'-Deoxyribonucleosides, Inorganic Radical, γ-Irradiation, Radical Reactions, Thymidine Oxidation