57992-77-5Relevant academic research and scientific papers
A simple one-pot procedure for the iminium salt formation: An efficient route to β-arylethylamines
Ku, Yi-Yin,Grieme, Tim,Pu, Yu-Ming,Bhatia, Ashok V.,King, Steve A.
, p. 1471 - 1474 (2007/10/03)
A practical and highly efficient process for the preparation of β-arylethylamines 7 was developed. Benzylic organozinc compounds 10 were reacted with the iminium salts 9 generated in situ from the amine salt 8 and paraformaldehyde in one pot and in a polar and aprotic solvent, such as NMP. A variety of the β-arylethylamines were prepared in 43-91% yields.
