2,5-bis(aziridin-1-yl)-3,6-bis(ethylsulfanyl)cyclohexa-2,5-diene-1,4-dione, commonly known as BCNU, is a chemotherapy drug that is utilized in the treatment of specific brain tumors, multiple myeloma, and lymphoma. It functions as a potent alkylating agent, attaching an alkyl group to DNA and thereby inhibiting DNA replication, which results in the death of cancer cells. Administered intravenously, BCNU targets rapidly dividing cancer cells and has been a successful component of cancer treatment for over four decades, despite its potential for significant toxic side effects, particularly to the bone marrow and gastrointestinal system.
57998-65-9
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Basic information
- Product Name: 2,5-bis(aziridin-1-yl)-3,6-bis(ethylsulfanyl)cyclohexa-2,5-diene-1,4-dione
- Synonyms:
- CAS NO:57998-65-9
- Molecular Formula: C14H18N2O2S2
- Molecular Weight: 310.4349
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 429.4°C at 760 mmHg
- Flash Point: 213.5°C
- Appearance: N/A
- Density: 1.38g/cm3
- Vapor Pressure: 1.41E-07mmHg at 25°C
- Refractive Index: 1.668
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 2,5-bis(aziridin-1-yl)-3,6-bis(ethylsulfanyl)cyclohexa-2,5-diene-1,4-dione(CAS DataBase Reference)
- NIST Chemistry Reference: 2,5-bis(aziridin-1-yl)-3,6-bis(ethylsulfanyl)cyclohexa-2,5-diene-1,4-dione(57998-65-9)
- EPA Substance Registry System: 2,5-bis(aziridin-1-yl)-3,6-bis(ethylsulfanyl)cyclohexa-2,5-diene-1,4-dione(57998-65-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 57998-65-9(Hazardous Substances Data)
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57998-65-9 Usage
Uses
Used in Oncology:2,5-bis(aziridin-1-yl)-3,6-bis(ethylsulfanyl)cyclohexa-2,5-diene-1,4-dione is used as a chemotherapy agent for the treatment of certain types of brain tumors, multiple myeloma, and lymphoma. It is effective due to its alkylating properties, which prevent DNA replication in cancer cells, leading to cell death.
Used in Cancer Treatment:
2,5-bis(aziridin-1-yl)-3,6-bis(ethylsulfanyl)cyclohexa-2,5-diene-1,4-dione is used as an intravenous medication to target and kill rapidly dividing cancer cells, playing a crucial role in the management of various malignancies. Despite its potential for toxic side effects, its efficacy in cancer treatment has been recognized and utilized for over 40 years.
Check Digit Verification of cas no
The CAS Registry Mumber 57998-65-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,9,9 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.Calculate Digit Verification of CAS Registry Number 57998-65:
(7*5)+(6*7)+(5*9)+(4*9)+(3*8)+(2*6)+(1*5)=199
199 % 10 = 9
So 57998-65-9 is a valid CAS Registry Number.
57998-65-9Upstream product
57998-65-9Downstream Products
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2,5-bis(aziridin-1-yl)-3,6-bis(ethylsulfanyl)cyclohexa-2,5-diene-1,4-dione
