KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE, commonly known as Kainic acid, is a cyclic analog of L-glutamate originally isolated from the red algae Digenea simplex. It acts as an agonist for kainate-class ionotropic glutamate receptors, which are excitatory and directly gate ion channels. Kainic acid is known for its neuroexcitatory activities and is used in various scientific and medical applications due to its ability to induce neurocytosis (apoptosis) and epileptic seizures.
58002-62-3
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Basic information
- Product Name: KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE
- Synonyms: 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE;2-CARBOXYL-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE MONOHYDRATE;[2S-(2A,3BETA,4BETA)]-2-CAROXY-4-(1-METHYLETHENYL)-3-PYRROLIDINEACETIC ACID, MONOHYDRATE;(2S,3S,4S)-2-CARBOXY-4-ISOPROPENYL-3-PYRROLIDINEACETIC ACID;KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE;(-)-KAINIC ACID, MONOHYDRATE;KAINIC ACID MONOHYDRATE;KAINIC ACID MONOHYDRATE, ISOLATED FROM D
- CAS NO:58002-62-3
- Molecular Formula: C10H17NO5
- Molecular Weight: 231.25
- EINECS: N/A
- Product Categories: Miscellaneous;Glutamate
- Mol File: 58002-62-3.mol
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Chemical Properties
- Melting Point: 250-252°C
- Boiling Point: 439.9 °C at 760 mmHg
- Flash Point: 219.8 °C
- Appearance: white/solid
- Density: N/A
- Vapor Pressure: 5.74E-09mmHg at 25°C
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: H2O: >10 mg/mL
- Sensitive: Light Sensitive
- CAS DataBase Reference: KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE(CAS DataBase Reference)
- NIST Chemistry Reference: KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE(58002-62-3)
- EPA Substance Registry System: KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE(58002-62-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: 22-24/25
- WGK Germany: 3
- RTECS: UX9665250
- F: 10
- TSCA: No
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 58002-62-3(Hazardous Substances Data)
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58002-62-3 Usage
Uses
Used in Neuroscience Research:KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE is used as a research tool for studying mechanisms of excitation-induced apoptosis and epilepsy. It helps researchers understand the underlying causes and pathways involved in these conditions.
Used in Epilepsy and Seizure Studies:
KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE is used as a convulsant to induce epileptogenesis and epilepsy in mice. It is also used to stimulate in vitro excitotoxic trauma in spiral ganglion neurons on inner hair cells, providing valuable insights into the effects of epilepsy on the nervous system.
Used in Animal Models:
KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE is used as a seizure-inducing agent in rat and mouse models. It is employed to induce seizures in rat models and status epilepticus in adult male Wistar rats, allowing researchers to study the effects of various treatments and potential therapeutic interventions.
Used in Neurodegenerative Disease Research:
KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE is used as a neurotoxin to induce apoptosis in primary neonatal cerebellar granule neurons. This application helps researchers investigate the mechanisms of neurodegeneration and develop potential treatments for neurodegenerative diseases.
Biochem/physiol Actions
Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.Check Digit Verification of cas no
The CAS Registry Mumber 58002-62-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,0,0 and 2 respectively; the second part has 2 digits, 6 and 2 respectively.Calculate Digit Verification of CAS Registry Number 58002-62:
(7*5)+(6*8)+(5*0)+(4*0)+(3*2)+(2*6)+(1*2)=103
103 % 10 = 3
So 58002-62-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1
58002-62-3 Well-known Company Product Price
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- (Code)Product description
- CAS number
- Packaging
- Price
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Sigma
(K0250) Kainic acid monohydrate ≥99% (TLC)
58002-62-3
K0250-10MG
1,766.70CNY
- Detail
Sigma
(K0250) Kainic acid monohydrate ≥99% (TLC)
58002-62-3
K0250-50MG
9,822.15CNY
- Detail
Sigma
(K2389) Kainic acid monohydrate ≥98% (HPLC), from Digenea simplex
58002-62-3
K2389-10MG
2,950.74CNY
- Detail
Sigma
(K2389) Kainic acid monohydrate ≥98% (HPLC), from Digenea simplex
58002-62-3
K2389-50MG
10,617.75CNY
- Detail
58002-62-3Upstream product
58002-62-3Downstream Products
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KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE
