58008-30-3

Usage

Molecular weight

174.24 g/mol

Physical state

White solid

Structural components

Dibenzofuran moiety, six-membered saturated ring

Potential applications

Organic synthesis, pharmaceuticals

Safety precautions

Handle with care, use in well-ventilated area, wear personal protective equipment.

Upstream product

• 1165952-91-9 cyclohexa-1,3-diene 
• 108-46-3 recorcinol 

Relevant academic research and scientific papers

Synthesis and inhibitory evaluation of cyclohexen-2-yl- and cyclohexyl-substituted phenols and quinones to endothelial cell and cancer cells

Alkylation of phenols with 1,3-cyclohexadiene (1) has been conducted and a series of cyclohexen-2-yl- and cyclohexyl-substituted phenols and quinones were screened against the proliferation of HUVEC and cancer cells. Phenol type as well as the size and occupied position of the substitute are important for the alkylating reaction and the inhibitory activity and selectivity of a compound. 2,5-Di(cyclohexen-2-yl)benzene-1,4-diol (25) bearing two cyclohexen-2-yl groups and 2-tert-butyl-5-(cyclohexen-2-yl)benzene-1,4-diol (30) bearing cyclohexen-2-yl and tert-butyl groups exhibited good selectivity against HUVEC proliferation (IC50s of 2.0 and 1.4?μM, respectively) with relatively low toxicity to ccc-HPF-1.