5803-22-5Relevant academic research and scientific papers
BICYCLIC INHIBITORS OF ALK
-
Page/Page column 87, (2012/08/07)
The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, wherein R1, X, Y, Z, A, B, G1, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.
BICYCLIC CARBOXAMIDE INHIBITORS OF KINASES
-
Page/Page column 86, (2012/08/07)
Compounds of formula (I) or pharmaceutical acceptable salts are provided, wherein X1~X5, R1~R3, A, B, Z and n are defined in the description. And compositions containing said compounds, and the uses for inhibitors of kinases such as ALK, and the uses for treating cancer thereof are provided.
Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors
Choi, Seoung-Ryoung,Pradhan, Anupam,Hammond, Nicholas L.,Chittiboyina, Amar G.,Tekwani, Babu L.,Avery, Mitchell A.
, p. 3841 - 3850 (2008/02/11)
Plasmodium falciparum lactate dehydrogenase (pfLDH) is a key enzyme for energy generation of malarial parasites and is a potential antimalarial chemotherapeutic target. It is known that the oxamate moiety, a pyruvate analog, alone shows higher inhibition
ALPHA-4 INTEGRIN MEDIATED CELL ADHESION INHIBITORS FOR THE TREATMENT OR PREVENTION OF INFLAMMATORY DISEASES
-
Page/Page column 41, (2010/02/13)
The present invention relates to novel compounds of formula (I), processes for their preparation, compositions comprising them and their use in the treatment or prevention of diseases capable of being modulated by the inhibition of cell adhesion.
