58040-60-1Relevant academic research and scientific papers
A Copper-Catalyzed Sonogashira Coupling Reaction of Diverse Activated Alkyl Halides with Terminal Alkynes Under Ambient Conditions
Cao, Yu-Xi,Dong, Xiao-Yang,Yang, Jun,Jiang, Sheng-Peng,Zhou, Shuangliu,Li, Zhong-Liang,Chen, Guo-Qiang,Liu, Xin-Yuan
supporting information, p. 2280 - 2284 (2020/05/08)
We describe a copper-catalyzed Sonogashira coupling reaction of alkyl halides with terminal alkynes under ambient conditions, efficiently providing a versatile tool for the construction of substituted alkynes. A new proline-based N,N,P-ligand is utilized to promote the transformation under a mild reaction condition. Diverse alkyl halides, such as primary and secondary (hetero)benzyl chlorides and bromides, secondary and tertiary α-bromo amides and propargylic bromide, are applicable to provide a wide array of alkynes. (Figure presented.).
SUBSTITUTION OF THE HYDROXYL GROUP IN ACETYLENIC ALCOHOLS BY HYDROGEN
Libman, N. M.,Shandybina, O. N.
, p. 2290 - 2293 (2007/10/02)
Tertiary α-alkynols containing at least one phenyl group at the acetylenic carbon atom are reduced by trialkyl- and triarylsilanes in the presence of trifluoroacetic acid to the corresponding acetylene hydrocarbons.
