58044-70-5

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 137-07-5 2-amino-benzenethiol 

Downstream Products

• 1015252-89-7 C₂₂H₂₂N₄O₂S₂ 
• 1258314-75-8 [(1Z)-1H-pyrrol-2-ylmethylene][2-[[4-[(2-[[(1Z)-1H-pyrrol-2-ylmethylene]amino]phenyl)thio]butyl]thio]phenyl]amine 
• 943986-88-7 1,4-bis[(2-chloroacetamido)thiophenoxy]butane 

Relevant academic research and scientific papers

Synthesis and characterization of some transition metal complexes with bis(o-aminophenyl)disulfide alkane ligands

A series of new complexes of the type [M(L)Cl2] and [M(L)]Cl2 where M= Co(II),Ni(II) and Cu(II), L=L1 or L2 {L1=1,2- Bis(o-aminophenyl)disulfide propane,L2=1,2-Bis(o- aminophenyl) disulfide butane, have been prepared in 1:1 (L:M) and characterized by mola

Bis(2-cyanoacetamides): Versatile precursors for bis(dihydropyridine-3,5-dicarbonitriles)

Bis(6-amino-1,2-dihydropyridine-3,5-dicarbonitriles) containing thioether linkages are prepared via the condensation of bis(cyanoacetamides) with α-substituted cinnamonitriles in the presence of piperidine. The target compounds can also be obtained via a three-component reaction of bis(cyanoacetamides) with two equivalents of both aldehydes and malononitrile in ethanol containing piperidine as a base.

Zinc oxide catalyzed solvent-free mechanochemical route for C-S bond construction: A sustainable process

A zinc oxide catalyzed solvent-free mechanochemical process has been developed for the rapid construction of C-S bonds by using a nucleophilic substitution reaction (SN2 mechanism) that involves a variety of thiols and phenacyl/ benzyl/alkyl bromides. Notable advantages of this method in-clude its broad substrate scope, clean reaction profile, safety, scalability, high product yields at ambient conditions, and the recyclability of the catalyst. Furthermore, the prepared compounds are valuable building blocks for the synthesis of various biologically active molecules.

Nickel(II) and copper(II) complexes of Schiff base ligands containing N4O2 and N4S2 donors with pyrrole terminal binding groups: Synthesis, characterization, X-ray structures, DFT and electrochemical studies

A series of hexadentate ligands, H2Lm (m = 1-4), [1H-pyrrol-2-ylmethylene]{2-[2-(2-{[1H-pyrrol-2-ylmethylene]amino}phenoxy) ethoxy]phenyl}amine (H2L1), [1H-pyrrol-2-ylmethylene]{2- [4-(2-{[1H-pyrrol-2-ylmethylene]amino}phenoxy)butoxy]phenyl}amine (H 2L2), [1H-pyrrol-2-ylmethylene][2-({2-[(2-{[1H-pyrrol-2- ylmethylene]amino}phenyl)thio]ethyl}thio)phenyl]amine (H2L 3) and [1H-pyrrol-2-ylmethylene][2-({4-[(2-{[1H-pyrrol-2-lmethylene] amino}phenyl)thio]butyl}thio) phenyl]amine (H2L4) were prepared by condensation reaction of pyrrol-2-carboxaldehyde with {2-[2-(2-aminophenoxy)ethoxy]phenyl}amine, {2-[4-(2-aminophenoxy)butoxy]phenyl} amine, [2-({2-[(2-aminophenyl)thio]ethyl}thio)phenyl]amine and [2-({4-[(2-aminophenyl)thio]butyl}thio)phenyl]amine respectively. Reaction of these ligands with nickel(II) and copper(II) acetate gave complexes of the form MLm (m = 1-4), and the synthesized ligands and their complexes have been characterized by a variety of physico-chemical techniques. The solid and solution states investigations show that the complexes are neutral. The molecular structures of NiL3 and CuL2, which have been determined by single crystal X-ray diffraction, indicate that the NiL 3 complex has a distorted octahedral coordination environment around the metal while the CuL2 complex has a seesaw coordination geometry. DFT calculations were used to analyse the electronic structure and simulation of the electronic absorption spectrum of the CuL2 complex using TDDFT gives results that are consistent with the measured spectroscopic behavior of the complex. Cyclic voltammetry indicates that all copper complexes are electrochemically inactive but the nickel complexes with softer thioethers are more easily oxidized than their oxygen analogs.

QSAR modeling, synthesis and bioassay of diverse leukemia RPMI-8226 cell line active agents

A rigorous QSAR modeling procedure employing CODESSA PRO descriptors has been utilized for the prediction of more efficient anti-leukemia agents. Experimental data concerning the effect on leukemia RPMI-8226 cell line tumor growth of 34 compounds (treated

Tetradentate diamido-bis-sulfide ligands on the base of o-aminobenzenethiol and their complexation with NiII, CoII, CuII chlorides in DMF solution and on the gold electrode surface

A series of cyclic and acyclic diamido-bis-sulfide ligands were synthesized by N-acylation of 1,2-bis(2-aminophenylthio)ethane and 1,4-bis(2- aminophenylthio)butane with acetic, malonic, and 3,3'-dithiodipropionic acid chlorides or esters. The complexation of obtained ligands with CuII, NiII, and CoII salts in solution and on the gold electrode surface was studied. The formation of complexes of these ligands with copper(II) chloride in DMF is irreversible and accompanied by deprotonation of the amide nitrogen atoms.