58064-75-8Relevant academic research and scientific papers
Synthesis, in vitro and in Silico studies of some novel 5-nitrofuran-2-yl hydrazones as antimicrobial and antitubercular agents
Abdel-Aziz, Hatem Abdel-Kader,Eldehna, Wagdy Mohamed,Fares, Mohamed,Elsaman, Tilal,Abdel-Aziz, Marwa Mostafa,Soliman, Dalia Hussein
, p. 1617 - 1630 (2015/11/24)
In this study, we synthesized two series of novel 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e in addition to a third series of thiophene-2-carbohydrazides 23a-g to develop potent antimicrobial and/or antitubercular agents. The newly synthesized compounds were evaluated in vitro for their antimicrobial and antimycobacterial activities. Most of the 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e displayed variable activity against Aspergillus fumigates, Staphylococcus aureus, Streptococcus pneumonia, Bacillis subtilis, Salmonella typhimurium, Klebsiella pneumonia, Escherichia coli and Mycobacterium tuberculosis. The sulfonamide derivative 21f exhibited superior potency and broad-spectrum antimicrobial activity with minimum inhibitory concentration (MIC)=0.06-0.98 μg/mL and antimycobacterial activity with MIC=3.9 μg/mL. The 5-nitrofuran-2-carbohydrazides 21a, b, g, h and 22a-c exhibited significant antibacterial activity with MIC values in the range of 0.12-7.81 μg/mL. The significances of the 5-nitrofuran moiety and sulfonamide function were explored via the structure-activity relationship (SAR) study. In addition, docking studies revealed that the p-amino benzoic acid (PABA) and binding pockets of the dihydropteroate synthase (DHPS) were successfully occupied by compound 21f. Furthermore, two quantitative structure-activity relationship (QSAR) models were built to explore the structural requirements which controlled the activity.
Synthesis, crystal structures and studies on Hg2+ sensing by the diazo derivatives of sulfathiazole and sulfamethoxazole
Upadhyay, K. K.,Upadhyay, Shalini,Kumar, Ajit,Thapliyal, Kamlesh
, p. 573 - 582,10 (2020/09/16)
Diazocoupling of sulfathiazole and sulfamethoxazole with 2,4-pentanedione led to the syntheses of compounds R1 and R2. These were fully characterized by single crystal X-ray diffraction studies in conjunction with UV-visible, IR, 1H NMR, and ma
Synthesis of some New Pyrazolin-5-ones
Jain, Rajeev,Gupta, Seema
, p. 325 - 325 (2007/10/03)
Synthesis of some sufonamoylhydrazonopyrazolin-5-ones have been reported.
