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Relevant academic research and scientific papers

Bismuth(III) trifluoromethanesulfonate and trifluoroacetate as convenient and efficient catalysts for regio- and chemoselective ring opening of epoxides in reactions with anilines

Bismuth(III) trifluoromethanesulfonate and trifluoroacetate are highly efficient and practical catalysts for oxirane ring opening in reactions of epoxides with substituted anilines. The reactions are characterized by high chemoselectivity and good to exce

Synthesis and application of Cu(II) immobilized MCM-41 based solid Lewis acid catalyst for aminolysis reaction under solvent-free condition

In this paper, a Cu(II) immobilized periodic mesoporous organosilica (PMOs) was synthesized and used as a reusable solid Lewis acid catalyst for the aminolysis of epoxides under solvent-free conditions. An amide-based ligand, L-propylsilyl (1) having a specific binding pocket was prepared and fabricated on mesoporous MCM-41 to produce mesoporous organosilica L-propylsilyl@MCM-41 (2). Further, it has been utilized for anchoring Cu(II) ions under controlled reaction conditions to yield solid Lewis acid catalyst Cu(II)-L-propylsilyl@MCM-41 (3). The synthesized catalyst 3 exhibits significantly higher catalytic activity for aminolysis compared to hitherto known solid Lewis acid catalysts. An extensive range of β-amino alcohols with high regio and stereoselectivity were prepared by using catalyst 3. The catalyst was recovered easily and reused eight times without any loss in its catalytic activity. Furthermore, the synthesis of clinically significant propranolol (β-blocker) from α- naphthyl glycidyl ether was attained successfully using catalyst 3 in a very decent yield.

Stereocontrolled, Divergent, Al(lll)-Catalyzed Coupling of Chiral N-Aryl Epoxy Amines and CO2

A divergent coupling reaction was achieved between N-aryl epoxy amines and CO2. By using two different cocatalysts, tetrabutylammonium iodide (TBAI) or 4-dimethylaminopyridine (DMAP) together with an Al(III) Lewis acid, cyclic carbonates or oxazolidinones were selectively produced through two distinct reaction pathways, respectively. The proposed reaction mechanism was supported by the stereochemical determination of the products. A gram-scale production of Linezolid was successfully achieved.

Post-synthesis of Zr-MOR as a robust solid acid catalyst for the ring-opening aminolysis of epoxides

Zirconosilicate with the MOR topology (Zr-MOR) was successfully prepared using a two-step post-synthesis strategy from pre-dealumination of a H-MOR zeolite and subsequent dry impregnation of Cp2ZrCl2. The incorporated Zr species main

An efficient method for regioselective ring opening of epoxides by amines under microwave irradiation using Bi(NO3)3·5H2O as a catalyst

Bismuth(iii)nitrate pentahydrate, a highly efficient environmentally benign catalyst, is used for the nucleophilic ring opening of epichlorohydrin and styrene oxide with aromatic, aliphatic and heteroaromatic amines under solvent free microwave conditions

An efficient protocol for regioselective ring opening of epoxides using sulfated tungstate: Application in synthesis of active pharmaceutical ingredients atenolol, propranolol and ranolazine

Sulfated tungstate was found to be a new and highly efficient catalyst for opening of epoxide rings by amines to give β-amino alcohols with high regioselectivity. Various advantages associated with this novel and environmental friendly protocol include solvent-free conditions, short reaction times, high product yields, simple workup procedure and easy recovery and reusability of the catalyst. This protocol has been applied for the synthesis of active pharmaceutical ingredients atenolol, propranolol and ranolazine.

Fe(III) substituted Wells-Dawson type polyoxometalate: An efficient catalyst for ring opening of epoxides with aromatic amines

Various β-aminoalcohols were prepared by the ring opening reaction of epoxides with aromatic amines in the presence of Fe(III) substituted Wells-Dawson type polyoxometalate, α2-[(n-C4H 9)4N]7P2/

Aminopropyl carbazole analogues as potent enhancers of neurogenesis

Neural stem cells are multipotent and self-renewing cells that can differentiate into new neurons and hold great promise for treating various neurological disorders including multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Small molecules that can trigger neurogenesis and neuroprotection are particularly useful not only because of their therapeutic implications but also because they can provide an invaluable tool to study the mechanisms of neurogenesis. In this report, we have developed and screened 25 aminopropyl carbazole derivatives that can enhance neurogenesis of cultured neural stem cells. Among these analogues, compound 9 demonstrated an excellent proneurogenic and neuroprotective activity with no apparent toxicity. We believe that compound 9 can serve as an excellent lead to develop various analogues and to study the underlying mechanisms of neurogenesis.

Efficient solvent-free aminolysis of epoxides under (C4H 12N2)2[BiCl6]Cl·H 2O catalysis

An efficient and rapid procedure for ring opening of various epoxides with aromatic, aliphatic and heterocyclic amines is developed at room temperature under solvent-free conditions in the presence of (C4H 12N2)2[BiCl6]Cl·H 2O (1 mol %). This catalyst can be reused several times without losing of its activity.

Synthesis of β-amino alcohols catalyzed by poly(vinyl chloride)-supported Schiff base metal complexes

Eight transition metal complexes of various Schiff bases supported on poly(vinyl chloride) (PVC) were prepared and characterized. These metal complexes were screened as heterogeneous catalysts in the synthesis of β-amino alcohols by ring opening of epoxid