5809-15-4

Basic information

• Product Name: 2-methyl-2-phenylpropanehydrazide
• CAS NO: 5809-15-4
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.231
• Mol File: 5809-15-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 360.3°C at 760 mmHg
• Flash Point: 171.7°C
• Density: 1.075g/cm³
• Vapor Pressure: 2.24E-05mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 2-methyl-2-phenylpropanehydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-2-phenylpropanehydrazide(5809-15-4)
• EPA Substance Registry System: 2-methyl-2-phenylpropanehydrazide(5809-15-4)

Safety Data

• Hazardous Substances Data: 5809-15-4(Hazardous Substances Data)

Upstream product

• 57625-74-8 methyl 2-methyl-2-phenylpropionate 
• 2901-13-5 ethyl 2-methyl-2-phenylpropionate 
• 826-55-1 2-methyl-2-phenylpropionic acid 

Downstream Products

• 252253-32-0 2-(1-methyl-1-phenylethyl)-1,3,4-oxadiazole 
• 372492-61-0 2-Methyl-2-phenyl-propionic acid [1-(4-amino-phenyl)-eth-(E)-ylidene]-hydrazide 
• 372492-63-2 2-Methyl-2-phenyl-propionic acid [1-(4-methoxy-phenyl)-eth-(E)-ylidene]-hydrazide 
• 1038320-22-7 4-amino-5-(2-phenylpropan-2-yl)-4H-[1,2,4]-triazole-3-thiol 
• 1341205-74-0 6-(4-fluorophenyl)-3-(2-phenylpropan-2-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1341205-75-1 3-(2-phenylpropan-2-yl)-6-(2,3,4-trifluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1341205-76-2 3-(2-phenylpropan-2-yl)-6-(2-thienyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1341205-77-3 3-(2-phenylpropan-2-yl)-6-(4-trifluoromethoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1341205-79-5 3-(2-phenylpropan-2-yl)-6-(4-trifluoromethylphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1415720-70-5 C₁₉H₁₆ClN₅O₂S 
• 1415720-69-2 C₂₀H₁₇F₃N₄OS 
• 1415720-68-1 C₁₉H₁₇ClN₄S 
• 1415720-67-0 C₁₉H₁₇BrN₄S 
• 1415720-66-9 C₂₀H₁₇N₅S 

Relevant articles and documents

Synthesis, spectral characterization and biological evaluation of a novel series of 6-arylsubstituted-3-[2-(4-substitutedphenyl)propan-2-yl]-7H-[1,2,4] triazolo[3,4-b][1,3,4]thiadiazines

On account of the reported anticancer activity of triazolothiadiazines, we have synthesized a novel series of 6-arylsubstituted-3-[2-(4-substitutedphenyl) propan-2-yl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and tested for in-vitro cytotoxicity by trypan blue exclusion and MTT assay. These compounds were also evaluated for their in-vivo anthelmintic activity, as well as in-vitro antimicrobial studies. Amongst the tested compounds, the compound 7j was the most promising cytotoxic agent with IC50 value of 10.54 μM in MCF-7 cells. The compounds 7l and 7q exhibited excellent anthelmintic activity. The compounds 7d, 7f, 7j, 7l, 7o, 7p and 7r showed good antibacterial activity, whereas compounds 7e and 7k exhibited excellent antifungal activity. The structures of newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and LCMS analysis.

Microwave assisted synthesis of novel pyrazoles

1,3,4-Trisubstituted pyrazoles synthesized by the reaction of 2-methyl-2-phenylpropanoyl hydrazide with substituted acetophenone followed by Vilsmeier Haack reagent (POCl3/DMF) under microwave irradiation (MWI) and by conventional methods are described. The reaction rate is enhanced tremendously under microwave irradiation as compared to conventional method with improved yields.