58096-27-8 Usage
Description
[1S-(1alpha,2beta,3alpha,5alpha)]-2,6,6-trimethylbicyclo[3.1.1]heptane-3-carboxylic acid, also known as norbornane-2-carboxylic acid, is a bicyclic organic compound with a carboxylic acid functional group. It features a tricyclic structure with three fused rings and three chiral centers, which provides it with stereoisomerism. [1S-(1alpha,2beta,3alpha,5alpha)]-2,6,6-trimethylbicyclo[3.1.1]heptane-3-carboxylic acid is known for its structural and stereochemical properties, making it a valuable component in the synthesis of pharmaceuticals and organic compounds.
Uses
Used in Pharmaceutical Synthesis:
[1S-(1alpha,2beta,3alpha,5alpha)]-2,6,6-trimethylbicyclo[3.1.1]heptane-3-carboxylic acid is used as a chiral building block for the synthesis of drugs and natural products. Its unique structural and stereochemical features make it a valuable component in creating complex molecular structures with specific biological activities.
Used in Organic Chemistry:
In the field of organic chemistry, [1S-(1alpha,2beta,3alpha,5alpha)]-2,6,6-trimethylbicyclo[3.1.1]heptane-3-carboxylic acid is utilized as a key intermediate in the synthesis of various organic compounds. Its carboxylic acid functional group allows for further reactions and modifications, contributing to the development of new molecules with potential applications in various industries.
Used in Chemical Research:
[1S-(1alpha,2beta,3alpha,5alpha)]-2,6,6-trimethylbicyclo[3.1.1]heptane-3-carboxylic acid is also employed in chemical research as a model for studying the effects of stereochemistry on molecular interactions and reactivity. Its three chiral centers provide a rich platform for investigating the influence of stereoisomerism on chemical and biological properties, which can lead to advancements in the understanding of molecular recognition and the design of more effective drugs and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 58096-27-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,0,9 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 58096-27:
(7*5)+(6*8)+(5*0)+(4*9)+(3*6)+(2*2)+(1*7)=148
148 % 10 = 8
So 58096-27-8 is a valid CAS Registry Number.
58096-27-8Relevant articles and documents
Design and synthesis of pinane oxime derivatives as novel anti-influenza agents
Dong, Jianghong,Xiao, Mengjie,Ma, Qinge,Zhang, Guicheng,Zhao, Weijie,Kong, Mengjie,Zhang, Yue,Qiu, Luyun,Hu, Wenhui
, (2020/08/05)
Parasitic characteristics, mutations and resistance of influenza A virus make it difficult for current influenza antiviral drugs to maintain long-term effectiveness. Currently, to design non-adamantane compounds targeting the S31N mutant of M2 proton channel is a promising direction for the development of novel anti-influenza drugs. In our previous research, a pinanamine-based antiviral M090 was discovered to target hemagglutinin instead of M2, with its structure being highly similar to reported M2-S31N inhibitors. Herein, a series of pinane oxime derivatives were designed from scratch and evaluated for anti-influenza activity and their cytotoxicity in vitro. Utilizing a combination of structure-activity relationship analysis, electrophysiological assay and molecular docking, the most potent compound 11h, as a M2-S31N blocker, exhibited excellent activity with EC50 value at the low micromolar level against both H3N2 and H1N1. No significant toxicity of 11h was observed. In addition, compound 11h was located tightly in the pore of the drug-binding site with the thiophene moiety facing down toward the C-terminus, and did not adopt a similar position and orientation as the reference inhibitor.
Transition Metal Catalyzed Oxidations in Perfluorinated Solvents
Klement, Ingo,Luetjens, Henning,Knochel, Paul
, p. 1454 - 1456 (2007/10/03)
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