58096-29-0Relevant articles and documents
Optically active transition-metal complexes, 8. - Transition-metal complexes of the optically active cyclopentadienyl ligand PinCp: Crystal structure of (S(Re))-(η5-PinCp)Re(No)(PPh3)[CONHCH(CH3)C10H7
Salzer, Albrecht,Hosang, Annegret,Knuppertz, Jutta,Englert, Ulli
, p. 1497 - 1505 (1999)
The synthesis of (η5-PinCp*)Re(CO)3 [PinCp* = tetramethyl(pinanyl)cyclopentadienyl] is described. Successive substitution of two CO ligands by NO+ and PPh3 generates a 1.1 diastereomeric mixture of chiral-at-met
Identification of camphor derivatives as novel M2 ion channel inhibitors of influenza A virus
Zhao, Xin,Zhang, Zhen-Wei,Cui, Wei,Chen, Shengwei,Zhou, Yang,Dong, Jianghong,Jie, Yanling,Wan, Junting,Xu, Yong,Hu, Wenhui
supporting information, p. 727 - 731 (2015/04/27)
Amantadine derivatives have been the only drugs marketed as M2 inhibitors of influenza A for decades. The identification of pinanamine as a novel M2 inhibitor suggests that M2 ion channels can accommodate more types of hydrophobic scaffolds. Herein, we further investigated the M2 ion channels and identified camphor derivatives as new types of M2 inhibitors. Compound 18 was found to be more potent than amantadine against wild-type influenza virus. The molecular docking revealed that compound 18 occupies more space in the M2 ion channel than amantadine and thus exhibits enhanced activity. This journal is
Pinane derivatives
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, (2008/06/13)
Pinanes substituted by a group X in the 3-position which group is formyl, or its alkyl-acetals or alkyl-hemiacetals, carboxylic acid, carboxylic acid chloride, carboxylic acid amide, hydroxymethyl or aminomethyl substituted in a specific manner at the nitrogen, the optical isomers of these compounds and a process for their manufacture by hydroformylation of α-pinene in the presence of rhodium catalysts, and conversion of the 3-formylpinane first produced into the above derivatives by conventional methods.
