581-71-5

Basic information

• Product Name: 3-hydroxynaphthalene-2-carbaldehyde
• Synonyms: 3-hydroxynaphthalene-2-carbaldehyde;2-Naphthalenecarboxaldehyde, 3-hydroxy-;3-Hydroxy-2-naphthaldehyde
• CAS NO: 581-71-5
• Molecular Formula: C₁₁H₈O₂
• Molecular Weight: 172.18
• Mol File: 581-71-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 98 °C
• Boiling Point: 317°C at 760 mmHg
• Flash Point: 134.3°C
• Appearance: /
• Density: 1.288g/cm³
• Vapor Pressure: 0.000213mmHg at 25°C
• Refractive Index: 1.719
• PKA: 7.77±0.40(Predicted)
• CAS DataBase Reference: 3-hydroxynaphthalene-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxynaphthalene-2-carbaldehyde(581-71-5)
• EPA Substance Registry System: 3-hydroxynaphthalene-2-carbaldehyde(581-71-5)

Safety Data

• Hazardous Substances Data: 581-71-5(Hazardous Substances Data)

Usage

Uses

3-Hydroxynaphthalene-2-carbaldehyde is a derivative of Naphthalene (N345600), an abundant polycyclic aromatic hydrocarbon that is persistent, bioaccumulative, toxic and found in tobacco smoke and urban air.

InChI:InChI=1/C11H8O2/c12-7-10-5-8-3-1-2-4-9(8)6-11(10)13/h1-7,13H

Upstream product

• 1621132-93-1 C₁₅H₁₆O₄ 
• 883-99-8 3-hydroxy-2-naphthoic acid methyl ester 
• 1621132-94-2 (3-(ethoxymethoxy)naphthalen-2-yl)methanol 

Downstream Products

• 1262864-70-9 C₂₃H₂₀O₄ 
• 13293-97-5 N-<3-Hydroxy-<2>naphthyl-methylen>-benzylamin 
• 220328-44-9 3-benzyloxynaphthalene-2-carbaldehyde 
• 119570-34-2 (4-chloro-phenyl)-naphtho[2,3-b]furan-2-yl ketone-(2,4-dinitro-phenylhydrazone) 
• 111616-88-7 naphtho[2,3-b]furan-2-yl-phenyl ketone semicarbazone 
• 73220-25-4 3-phenyl-2H-benzo[g]chromen-2-one 
• 87004-81-7 1-(nafto<2,3-b>furan-2-il)-2-isopropilammino-1-idrossietano 
• 28215-42-1 (3-hydroxy-naphthalen-2-yl)-phenyl-methanone 

Relevant articles and documents

Development of Photoactivatable Nitroxyl (HNO) Donors Incorporating the (3-Hydroxy-2-naphthalenyl)methyl Phototrigger

A new family of photoactivatable HNO donors of general structure RSO2NHO-PT [where PT represents the (3-hydroxy-2-naphthalenyl)methyl (3,2-HMN) phototrigger] has been developed, which rapidly releases HNO. Photogeneration of HNO was demonstrated using the vitamin B12 derivative aquacobalamin as a trapping agent. The amount of sulfonate RSO2– produced was essentially the same as the amount of HNO released upon photolysis, providing a convenient method to indirectly quantify HNO release. Two competing pathways were also observed; a pathway involving O–N bond cleavage leading to release of a sulfonamide, and a pathway resulting in release of the parent Nhydroxysulfonamide RSO2NHOH (for HNO donors with Me- and Ph-containing leaving groups only). Up to approximately 70 % of the HNO-generating pathway was observed with the CF3-containing leaving group, with HNO generation favored for small percentages of aqueous buffer in the acetonitrile/pH 7.00 phosphate buffer solvent mixture. Characterization of the photoproducts obtained from steady-state irradiation by NMR spectroscopy showed that the desired HNO-generating pathway was less favored for HNO donors with Me- and Ph-containing leaving groups compared to the CF3-containing leaving group, suggesting that the excellent CF3-containing leaving group promotes HNO generation.