5810-22-0

Usage

Uses

Used in Pharmaceutical Industry:
Trimethoprim is used as an antibiotic for the treatment of bacterial infections. It works by inhibiting the production of folic acid in bacteria, which is essential for their survival and growth. This action helps to eliminate the bacteria and alleviate the infection.
Used in Combination Therapy:
Trimethoprim is often used in combination with sulfamethoxazole to create the antibiotic co-trimoxazole. This combination has a broad spectrum of activity against both gram-positive and gram-negative bacteria, making it a versatile treatment option for various bacterial infections.
Used in Urinary Tract Infections:
Co-trimoxazole, which contains trimethoprim, is commonly used to treat urinary tract infections. The combination of trimethoprim and sulfamethoxazole effectively targets the bacteria causing the infection, leading to a faster recovery.
Used in Respiratory Infections:
Trimethoprim, either alone or in combination with sulfamethoxazole, is also used to treat respiratory infections such as bronchitis and pneumonia. The antibiotic action of trimethoprim helps to clear the infection and alleviate symptoms.
Used in Other Bacterial Infections:
Trimethoprim and its combination with sulfamethoxazole, co-trimoxazole, are used to treat a variety of other bacterial infections, including skin infections, ear infections, and prostatitis. The broad-spectrum activity of the combination makes it a valuable tool in the treatment of multiple types of bacterial infections.

Upstream product

• 931-88-4 1,2-cyclooctene 
• 629-40-3 octanedinitrile 

Downstream Products

• 1002-57-9 8-Aminooctanoic acid 

Relevant academic research and scientific papers

Transformations of peroxide products of olefin ozonolysis in tetrahydrofuran in reactions with hydroxylamine and semicarbazide hydrochlorides

Treatment with hydroxylamine and semicarbazide hydrochlorides of peroxide products obtained by ozonolysis of olefins in tetrahydrofuran gives mainly carboxylic acids and their derivatives.

Selective hydrolysis of aliphatic dinitriles to monocarboxylic acids by a nitrilase from Arabidopsis thaliana

The hydrolysis of a variety of dinitriles including α,ω-dicyanoalkanes 1, β-substituted glutaronitriles 5, and γ-cyanopimelonitrile 7 with a recombinant plant nitrilase from Arabidopsis thaliana, expressed in E. coli, is described. Conversion rate and selectivity of the hydrolysis of dinitriles 1a-f to ω-cyanocarboxylic acids 2a-f depend on the chain length. The enzyme activity markedly increases from malononitrile (1a) to octanedinitrile (1f). The selectivity, however, does not correlate with the rates. Up to a chain length of 6 C-atoms, the cyanocarboxylic acid is the only product, even at complete conversion of the starting material. Pimelonitrile (1e) is hydrolyzed to the cyanocarboxylic acid 2e without formation of diacid (1%) up to 73% conversion. Glutaronitriles 5a-c were also hydrolyzed to the corresponding cyanobutanoic acids 6a-c with perfect selectivity. The nitrilase hydrolyzes exclusively the primary cyano group of 7 to give 3,5-dicyanoheptanoic acid (8a), whereby the selectivity is slightly reduced compared to the unsubstituted pimelonitrile (1e). If the hydrolysis is terminated at conversions ≤90%, pure 8a can be isolated in 72% yield (92% referred to conversion). After esterification of 8a to the methyl ester 8b, only the 5-cyano group but not the ester function was hydrolyzed enzymatically to give cyanoheptanedioic acid monoester (10).