SPDP-PEG4-acid is a PEG linker containing SPDP crosslinker and carboxylic acid moieties. SPDP is reactive toward thiol groups and contains a cleavable disulfide bond. Its membrane permeability allows for intracellular crosslinking reactions. The terminal carboxylic acid can react with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic properties of the PEG linkers increase compound solubility in aqueous media.
581065-97-6
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Basic information
- Product Name: SPDP-PEG4-acid
- Synonyms: SPDP-PEG4-acid;SDPD-PEG4-COOH
- CAS NO:581065-97-6
- Molecular Formula: C19H30N2O7S2
- Molecular Weight: 462.5807
- EINECS: N/A
- Product Categories: N/A
- Mol File: 581065-97-6.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 677.3±55.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.27±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 4.28±0.10(Predicted)
- CAS DataBase Reference: SPDP-PEG4-acid(CAS DataBase Reference)
- NIST Chemistry Reference: SPDP-PEG4-acid(581065-97-6)
- EPA Substance Registry System: SPDP-PEG4-acid(581065-97-6)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 581065-97-6(Hazardous Substances Data)
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581065-97-6 Usage
Uses
Used in Pharmaceutical Industry:SPDP-PEG4-acid is used as a crosslinking agent for targeting thiol-containing biomolecules due to its reactivity with thiol groups and the presence of a cleavable disulfide bond. This property enables it to be used in the development of drugs that require specific targeting and controlled release.
Used in Drug Delivery Systems:
SPDP-PEG4-acid is used as a component in the design of drug delivery systems to enhance the solubility and bioavailability of therapeutic agents. The hydrophilic PEG linkers improve the compound's solubility in aqueous media, which can be beneficial for the formulation of drugs with poor water solubility.
Used in Bioconjugation:
SPDP-PEG4-acid is used as a bioconjugation agent to form stable amide bonds with primary amines in the presence of activators such as EDC and HATU. This application is useful for the development of conjugated drugs, where the SPDP-PEG4-acid can be used to attach a therapeutic agent to a targeting moiety, such as an antibody or a peptide.
Used in Diagnostics:
SPDP-PEG4-acid can be used as a component in the development of diagnostic tools, such as imaging agents or biosensors, that require specific targeting and controlled release properties. The reactivity with thiol groups and the presence of a cleavable disulfide bond make it a suitable candidate for these applications.
Check Digit Verification of cas no
The CAS Registry Mumber 581065-97-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,8,1,0,6 and 5 respectively; the second part has 2 digits, 9 and 7 respectively.Calculate Digit Verification of CAS Registry Number 581065-97:
(8*5)+(7*8)+(6*1)+(5*0)+(4*6)+(3*5)+(2*9)+(1*7)=166
166 % 10 = 6
So 581065-97-6 is a valid CAS Registry Number.
581065-97-6Upstream product
581065-97-6Downstream Products
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SPDP-PEG4-acid
