58107-53-2Relevant academic research and scientific papers
A One-Pot Reaction toward the Diastereoselective Synthesis of Substituted Morpholines
Aubineau, Thomas,Cossy, Janine
, p. 7419 - 7423 (2018/12/11)
The diastereoselective synthesis of various substituted morpholines has been achieved from vinyloxiranes and amino-alcohols under sequential Pd(0)-catalyzed Tsuji-Trost/Fe(III)-catalyzed heterocyclization. Using the same strategy, 2,6-, 2,5-, and 2,3-disubstituted as well as 2,5,6- and 2,3,5-trisubstituted morpholines were obtained in good to excellent yields and diastereoselectivities.
Synthesis of 1,2-amino alcohols via catalytic C-H amidation of sp3 methyl C-H bonds
Kang, Taek,Kim, Heejeong,Kim, Jeung Gon,Chang, Sukbok
supporting information, p. 12073 - 12075 (2014/12/11)
Herein a new synthetic route to 1,2-amino alcohols is presented by using C-H amidation of sp3 methyl C-H bonds as a key step. Readily available alcohols were employed as starting materials after converting them to removable ketoxime chelating g
Gold-catalyzed direct activation of allylic alcohols in the stereoselective synthesis of functionalized 2-vinyl-morpholines
Bandini, Marco,Monari, Magda,Romaniello, Alessandro,Tragni, Michele
supporting information; body text, p. 14272 - 14277 (2011/03/19)
Alcohol versus alcohol: A highly stereocontrolled synthesis of substituted morpholines is realized by means of gold-catalyzed dehydrative allylic cyclization of diols (see scheme for one example; segphos = 5,5′-bis[di(3, 5-di-tert-butyl-4-methyoxyphenyl)phosphine]-4,4′-bi-1,3-benzodioxole). The present methodology represents one of the few examples of enantioselective gold-catalyzed transformations involving unactivated alkenes. Copyright
