581075-65-2

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 868697-19-2 3-allyl-2-methyl-penta-3,4-dienoic acid ethyl ester 
• 2749-86-2 hex-5-en-2-yn-1-ol 
• 581075-63-0 2-methyl-3-allylpenta-3,4-dien-1-ol 

Relevant academic research and scientific papers

Studies on Pd0-catalyzed cyclization of N-3,4-alkadienyl toluenesulfonamides with organic halides: Selective synthesis of 2,3-dihydropyrroles, 1,2,3,6-tetrahydropyrridines, and azetidines

The palladium-catalyzed coupling-cyclization of β-amino allenes with organic halides ranging from aryl halide to 1-alkenyl halide was studied. 2,3-Dihydro-1H-pyrroles were obtained by reaction of 3-substituted-5- unsubstituted-3,4-allenyl amides under conditions A, while the reaction of 5-substituted-3,4-allenyl amides afforded 1,2,5,6-tetrahydropyridines and/or azetidines with high de under conditions B or C. The skeleton and relative configuration of the six-membered products were established by the X-ray diffraction studies of 10ka. Allenyl amide 4q reacted with 1,4-diiodobenzene 6r to afford double cyclization product 15. The structure of its major stereoisomer was also determined by the X-ray diffraction study.

Studies on Pd(II)-catalyzed coupling-cyclization of α- or β-amino allenes with allylic halides

The palladium-catalyzed coupling-cyclization of α- or β-amino allenes with allylic halides leading to 3-allylic 2,5-dihydropyrroles and 1,2,3,6-tetrahydropyridines, respectively, was studied. The starting materials are easily available. The skeletons of b