58110-57-9

Basic information

• Product Name: 5-(2-BROMO-PHENYL)-FURAN-2-CARBALDEHYDE
• Synonyms: 2-furancarboxaldehyde, 5-(2-bromophenyl)-;5-(2-bromophenyl)-2-furancarboxaldehyde;5-(2-bromophenyl)furfural
• CAS NO: 58110-57-9
• Molecular Formula: C₁₁H₇BrO₂
• Molecular Weight: 251.09
• Mol File: 58110-57-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 357.1°Cat760mmHg
• Flash Point: 169.8°C
• Appearance: /
• Density: 1.518g/cm³
• Vapor Pressure: 2.79E-05mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: 5-(2-BROMO-PHENYL)-FURAN-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-BROMO-PHENYL)-FURAN-2-CARBALDEHYDE(58110-57-9)
• EPA Substance Registry System: 5-(2-BROMO-PHENYL)-FURAN-2-CARBALDEHYDE(58110-57-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 58110-57-9(Hazardous Substances Data)

Usage

General Description

5-(2-Bromo-phenyl)-furan-2-carbaldehyde is a chemical compound with the molecular formula C11H7BrO2. It is a derivative of furan and contains a furan ring with a 2-bromo-phenyl group and a carbaldehyde functional group. 5-(2-BROMO-PHENYL)-FURAN-2-CARBALDEHYDE is commonly used in organic synthesis and pharmaceutical research due to its ability to serve as a versatile building block for the synthesis of various organic compounds. It has been studied for its potential biological activities and has shown promising results in various pharmacological assays. This chemical compound is an important intermediate in the synthesis of various pharmaceuticals and agrochemicals.

InChI:InChI=1/C11H7BrO2/c12-10-4-2-1-3-9(10)11-6-5-8(7-13)14-11/h1-7H

Upstream product

• 98-01-1 furfural 
• 615-36-1 2-bromoaniline 

Downstream Products

• 54023-05-1 5-(2-bromophenyl)furan-2-carboxylic acid 
• 1032338-04-7 C₁₉H₁₂BrF₂NO₄ 
• 1032338-28-5 C₁₉H₁₂BrCl₂NO₄ 
• 88649-67-6 5-(2-Bromo-phenyl)-furan-2-carboximidic acid methyl ester 
• 88649-66-5 5-(2-Bromo-phenyl)-furan-2-carbonitrile 
• 129626-58-0 2-(2-Bromo-phenyl)-5-[(E)-2-(2-bromo-phenyl)-vinyl]-furan 
• 349099-16-7 C₁₈H₁₅BrN₂O₃S 
• 88649-65-4 5-(2'-bromophenyl)-2-furaldehyde oxime 
• 129626-52-4 (E)-3-[5-(2-Bromo-phenyl)-furan-2-yl]-acrylic acid 

Relevant articles and documents

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

NMDA receptors mediate glutamatergic neurotransmission and are therapeutic targets due to their involvement in a variety of psychiatric and neurological disorders. Here, we describe the design and synthesis of a series of (R)-3-(5-furanyl)carboxamido-2-am

Reaction of substituted furan-2-carboxaldehydes and furo[b]pyrrole type aldehydes with hippuric acid

4-Heteroarylidene-2-phenyl-1,3-oxazol-5(4H)-ones were prepared by reactions of hippuric acid with substituted furan-2-carboxaldehydes or furo[b]pyrrole type aldehydes. The reactivity of various furan-2-carboxaldehyde derivatives in this reaction is discussed. The effect of microwave irradiation on some condensation reactions was compared with "classical" conditions. The results show that microwave irradiation shortens the reaction times while affording comparable yields. Elementary analysis, UV, IR and 1D NMR proved the structure of new synthesised compounds. 2D NMR spectroscopic measurements confirmed that the configuration at the carbon-carbon double bond corresponds to the pure E isomers of the products.

5-Phenyl-2-furamidines: A new chemical class of potential antidepressants

A series of 5-phenyl-2-furamidines has been synthesized and evaluated for antidepressant activities. Substitution in the phenyl ring with a nitro (4) or an amino (12) group in the ortho-position resulted in an increase in antidepressant activity. Both 4 and 12 antagonized tetrabenazine-induced ptosis in rodents and inhibited norepinephrine (noradrenaline) uptake into crude synaptosomes of whole mouse brain at doses or concentrations comparable to those of the tricyclic antidepressants. However, these compounds did not possess the anticholinergic and antihistaminic activities common to tricyclic antidepressants. In addition, they lacked monoamine oxidase inhibitory activity. The 5-phenyl-2-furamidines represent a new chemical class of antidepressants and may be useful for depressive patients who cannot tolerate the compromising side effects of the tricyclic antidepressants and monoamine oxidase inhibitors.