58110-57-9

Usage

Uses

Used in Organic Synthesis:
5-(2-BROMO-PHENYL)-FURAN-2-CARBALDEHYDE is used as a versatile building block in organic synthesis for its ability to form various organic compounds, contributing to the development of new chemical entities with potential applications in different fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-(2-BROMO-PHENYL)-FURAN-2-CARBALDEHYDE is utilized as a key intermediate in the synthesis of pharmaceuticals. Its unique structure allows for the exploration of its potential biological activities, which have shown promising results in pharmacological assays, indicating its potential use in the development of new drugs.
Used in Agrochemicals:
5-(2-BROMO-PHENYL)-FURAN-2-CARBALDEHYDE also serves as an important intermediate in the synthesis of agrochemicals, where its chemical properties can be leveraged to create compounds with applications in agriculture, such as pesticides or herbicides, to improve crop protection and yield.

InChI:InChI=1/C11H7BrO2/c12-10-4-2-1-3-9(10)11-6-5-8(7-13)14-11/h1-7H

Upstream product

• 98-01-1 furfural 
• 615-36-1 2-bromoaniline 

Downstream Products

• 129626-52-4 (E)-3-[5-(2-Bromo-phenyl)-furan-2-yl]-acrylic acid 
• 349099-16-7 C₁₈H₁₅BrN₂O₃S 
• 54023-05-1 5-(2-bromophenyl)furan-2-carboxylic acid 
• 1032338-04-7 C₁₉H₁₂BrF₂NO₄ 
• 1032338-28-5 C₁₉H₁₂BrCl₂NO₄ 
• 88649-67-6 5-(2-Bromo-phenyl)-furan-2-carboximidic acid methyl ester 
• 88649-66-5 5-(2-Bromo-phenyl)-furan-2-carbonitrile 
• 129626-58-0 2-(2-Bromo-phenyl)-5-[(E)-2-(2-bromo-phenyl)-vinyl]-furan 
• 88649-65-4 5-(2'-bromophenyl)-2-furaldehyde oxime 

Relevant academic research and scientific papers

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

NMDA receptors mediate glutamatergic neurotransmission and are therapeutic targets due to their involvement in a variety of psychiatric and neurological disorders. Here, we describe the design and synthesis of a series of (R)-3-(5-furanyl)carboxamido-2-am

Synthesis and fungicidal activity of aryl carbamic acid-5-aryl-2- furanmethyl ester

Chitin, a major structural component of insect cuticle and fungus cell wall but absent in plants and vertebrates, is regarded as a safe and selective target for pest control agents. Chitin synthesis inhibitors (CSIs) have been well-known as insect growth regulators (IGRs) but rarely found as fungicides in agriculture. To find novel CSIs with good activity, benzoylphenylurea, a typical kind of CSIs, was chosen as the lead compound and 26 novel aryl carbamic acid-5-aryl-2-furanmethyl esters were designed by converting the urea linkages of benzoylphenylureas to carbamic acid esters and changing the aniline parts into furanmethyl groups. The title compounds were synthesized and their structures confirmed by IR, 1H NMR, and elemental analysis. Preliminary insecticidal and fungicidal bioassays were carried out. The results indicated that the title compounds had no insecticidal effect on Culex pipiens pallens and Plutella xylostella Linnaeus, but most compounds exhibited good fungicidal activities against Corynespora cassiicola, Thanatephorus cucumeris, Botrytis cinerea, and Fusarium oxysporum. In particular, compounds V-4, V-6, V-7, and V-8 showed better activities against the four strains than those of the commercialized fungicides. The morphologic result suggested that compound V-21 had disturbed the cell wall formation of C. cassiicola. The results indicated that modification on the urea linkage of benzoylphenylurea was an effective way to discover new candidates for fungicides.

Reaction of substituted furan-2-carboxaldehydes and furo[b]pyrrole type aldehydes with hippuric acid

4-Heteroarylidene-2-phenyl-1,3-oxazol-5(4H)-ones were prepared by reactions of hippuric acid with substituted furan-2-carboxaldehydes or furo[b]pyrrole type aldehydes. The reactivity of various furan-2-carboxaldehyde derivatives in this reaction is discussed. The effect of microwave irradiation on some condensation reactions was compared with "classical" conditions. The results show that microwave irradiation shortens the reaction times while affording comparable yields. Elementary analysis, UV, IR and 1D NMR proved the structure of new synthesised compounds. 2D NMR spectroscopic measurements confirmed that the configuration at the carbon-carbon double bond corresponds to the pure E isomers of the products.

2-(5-phenyl-2-furanyl)imidazoles useful as cardiotonic agents

The present invention involves certain 2-(5-phenyl-2-furanyl)-imidazoles, pharmaceutical compositions containing such compounds, and methods for enhancing the contractile force of cardiac muscle of a mammal which comprises systemically administering such

5-Phenyl-2-furamidines: A new chemical class of potential antidepressants

A series of 5-phenyl-2-furamidines has been synthesized and evaluated for antidepressant activities. Substitution in the phenyl ring with a nitro (4) or an amino (12) group in the ortho-position resulted in an increase in antidepressant activity. Both 4 and 12 antagonized tetrabenazine-induced ptosis in rodents and inhibited norepinephrine (noradrenaline) uptake into crude synaptosomes of whole mouse brain at doses or concentrations comparable to those of the tricyclic antidepressants. However, these compounds did not possess the anticholinergic and antihistaminic activities common to tricyclic antidepressants. In addition, they lacked monoamine oxidase inhibitory activity. The 5-phenyl-2-furamidines represent a new chemical class of antidepressants and may be useful for depressive patients who cannot tolerate the compromising side effects of the tricyclic antidepressants and monoamine oxidase inhibitors.