58137-45-4

Usage

Uses

Used in Pharmaceutical Industry:
2,4(1H,3H)-Pyrimidinedione, 6-[(4-chlorophenyl)amino]-3-methylis used as a building block for the synthesis of various drugs due to its unique chemical structure and potential therapeutic properties.
Used in Anticancer Applications:
In the field of oncology, 2,4(1H,3H)-Pyrimidinedione, 6-[(4-chlorophenyl)amino]-3-methylis being studied for its potential use in the treatment of cancer. Its antitumor and anticancer properties make it a promising candidate for further research and development in this area.
Used in Enzyme and Protein Kinase Inhibition:
2,4(1H,3H)-Pyrimidinedione, 6-[(4-chlorophenyl)amino]-3-methylhas been investigated for its role in inhibiting certain enzymes and protein kinases, which could have implications for the development of drugs targeting various diseases and conditions. Its ability to modulate these biological processes makes it a valuable compound for drug discovery and therapeutic intervention.

Upstream product

• 106-47-8 4-chloro-aniline 
• 4318-56-3 3-methyl-6-chlorouracil 

Downstream Products

• 90987-50-1 8-Chloro-10-(4-chloro-phenyl)-3-methyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 69083-38-1 10-(4-chloro-phenyl)-3-methyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 79157-27-0 10-(4-Chlorophenyl)-3,7-dimethylpyrido<2,3-d:6,5-d'>pyrimidine 
• 92978-22-8 8-(4-Chloro-phenyl)-3-methyl-2,4-dioxo-7-phenyl-2,3,4,8-tetrahydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid 
• 92978-44-4 6-benzoyl-1,2,3,4,7,8-hexahydro-3-methyl-8(4-chlorophenyl)-2,4,7-trioxopyrido<2,3-d>pyrimidine 
• 1079130-08-7 C₃₉H₅₀ClN₃O₂ 
• 130806-37-0 8-(4'-chlorophenyl)-3-methyl-6,7-diphenylpteridine-2,4(3H,8H)-dione 
• 130806-35-8 8-(4'-chlorophenyl)-3,6,7-trimethylpteridine-2,4(3H,8H)-dione 
• 130806-33-6 8-(4'-chlorophenyl)-3-methylpteridine-2,4(3H,8H)-dione 
• 130806-31-4 5-amino-6-(4'-chloroanilino)-3-methylpyrimidine-2,4(1H,3H)-dione 
• 130806-28-9 6-(4'-chloroanilino)-3-methyl-5-nitrosopyrimidine-2,4(1H,3H)-dione 
• 92978-35-3 ethyl 2,3,4,8-tetrahydro-3-methyl-2,4-dioxopyrido-7-phenyl-8-(4-chlorophenyl)<2,3-d>pyrimidine-6-carboxylate 
• 76896-39-4 C₂₉H₂₄Cl₂N₆O₄ 

Relevant academic research and scientific papers

Synthesis, biological active molecular design, and molecular docking study of novel deazaflavin-cholestane hybrid compounds

Novel deazaflavin-cholestane hybrid compounds, 3′,8′-disubstituted-5′-deazacholest-2,4-dieno[2,3-g]pteridine-2′,4′(3′H,8′H)-diones, have been synthesized by condensation reaction between 6-(monosubstituted amino)-pyrimidin-2,4(1H,3H)-diones and 2-hydroxymethylenecholest-4-en-3-one in presence of p-toluenesulfonic acid monohydrate and diphenyl ether. The antitumor activities against human tumor cell lines (CCRF-HSB-2 and KB cells) have been investigated in vitro, and many of these compounds showed promising antitumor activities. Furthermore, molecular docking study using LigandFit within the software package Discovery Studio 1.7 was done for lead optimization of these compounds as potential PTK inhibitors. In general, all of the synthesized steroid-hybrid compounds showed good binding affinities into PTK (PDB code: 1t46).

Autorecycling Oxidation of Alcohols Catalysed by Pyridopyrimidines as an NAD(P)(1+) Model

Two kinds of pyridopyrimidines as new NAD-type redox catalysts, 3,7,10-trisubstituted pyridodipyrimidine-2,4,6,8(1H,3H,7H,10H)-tetraones 6 and 3,8,10-trisubstituted pyridodipyrimidine-2,4,6(3H,7H,10H)-triones 7, have been synthesized by the condensation of 6-(substituted-amino)uracils 9 and 6-(substituted-amino)-2-phenylpyrimidin-4(3H)-ones 11 with appropriate 6-chloro-5-formyluracils 12 or 2,4,6-trichloropyrimidine-5-carbaldehyde 13 in dimethylformamide (DMF) or acetic acid.Compounds 6 and 7 have been found to oxidize a variety of alcohols under neutral conditions (in the absence of base) to yield the corresponding carbonyl compounds, catalytically with a markedly high turnover number.The oxidation yields were promoted remarkably depending upon the presence of lipophilic substituents, particularly due to the presence of longer alkyl groups at the 10-position.These catalysts are so stable that the oxidation reaction proceeds until the substrate is exhausted.

Flavins as Potential Antimalarials. 1. 10-(Halophenyl)-3-methylflavins

A series of 10-(halomethyl)-3-methylflavins was prepared by the condensation of 6-(haloanilino)-3-methyluracils with nitrosobenzene.A number of these flavins effectively cured lethal Plasmodium vinckei malarial infections in mice when administered by eith