58137-72-7

Basic information

• Product Name: 3a,8a-dihydroxy-1,3-diphenyl-1,3,3a,8a-tetrahydro-indeno[1,2-d]imidazole-2,8-dione
• Synonyms: 3a,8a-dihydroxy-1,3-diphenyl-1,3,3a,8a-tetrahydro-indeno[1,2-d]imidazole-2,8-dione
• CAS NO: 58137-72-7
• Molecular Weight: 372.38
• Mol File: 58137-72-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3a,8a-dihydroxy-1,3-diphenyl-1,3,3a,8a-tetrahydro-indeno[1,2-d]imidazole-2,8-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3a,8a-dihydroxy-1,3-diphenyl-1,3,3a,8a-tetrahydro-indeno[1,2-d]imidazole-2,8-dione(58137-72-7)
• EPA Substance Registry System: 3a,8a-dihydroxy-1,3-diphenyl-1,3,3a,8a-tetrahydro-indeno[1,2-d]imidazole-2,8-dione(58137-72-7)

Safety Data

• Hazardous Substances Data: 58137-72-7(Hazardous Substances Data)

Upstream product

• 485-47-2 indan-1,2,3-trione hydrate 
• 102-07-8 bis(diphenyl)urea 
• 62-53-3 aniline 
• 103-71-9 phenyl isocyanate 

Relevant articles and documents

Synthesis, antimicrobial and cholinesterase enzymes inhibitory activities of indeno imidazoles and X-ray crystal structure of 3a,8a-dihydroxy-1,3- diphenyl-1,3,3a,8a-tetrahydro-indeno [1,2-d]imidazole-2,8-dione

Two indeno imidazoles have been synthesized by the reaction of ninhydrin with diphenylurea and diphenylthiourea. The structures have been determined by spectral analysis. The supramolecular behavior of 3a,8a-Dihydroxy- 1,3-diphenyl-1,3,3a,8a-tetrahydro-indeno[1,2-d]imidazole- 2,8-dione (1) was thoroughly analyzed and reported using X-ray single crystal technique and concepts. The presence of oxygen and nitrogen atoms led to very interesting supramolecularmotifs interactions such as nitrogen-oxygen, nitrogen- nitrogen, oxygen-oxygen, nitrogen-hydrogen, and oxygen- hydrogen. 3a,8a-dihydroxy-1,3- diphenyl-2-thioxo-2,3,3a,8atetrahydro- 1H-indeno[1,2-d]imidazol-8-one 2 showed good antibacterial activity against B. subtilis and P. aeruginosa, while 3a,8a-dihydroxy-1,3-diphenyl-1,3,3a,8a-tetrahydroindeno[ 1,2-d]imidazole-2,8- dione 1 only showed antibacterial activity against P. aeruginosa. Both of 1 and 2 were inactive against C. albicans. Derivative 2 demonstrated good cholinesterase enzyme activity unlike derivative 1 which has weak inhibitory activity against these enzymes. Furthermore, 2 was found to be a selective butyrylcholinesterase enzyme inhibitor that has potential use for prevention of further neurodegeneration as well for symptomatic treatment of Alzheimer patients. Springer Science+Business Media, LLC 2012.

Synthesis and anticonvulsant activity of some 2,4-disubstituted-2,4-benzodiazocine-1,3,5,6-tetrones, 1-mono and 1,3- disubstituted indenoimidazoles and 2-substituted imidazoisoindoles

1-Mono and 1,3- disubstituted indeno[1,2-d] imidazolones were synthesized by reaction of appropriately mono- and disubstituted ureas with ninhydrin, in aqueous alcohol and heat. Oxidation of these with sodium metaperiodate formed the corresponding imidazo