58138-48-0Relevant articles and documents
2-Cyano indan-1,3-diones
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, (2008/06/13)
Pharmaceutical compositions are produced comprising as the active ingredient a compound of the formula STR1 or a pharmaceutically acceptable, nontoxic salt thereof or hydrate thereof, wherein R1, R2, R3 and R4 are each hydrogen, halogen, lower alkyl or lower alkoxy, or any two of the groups R1, R2, R3 and R4, taken together with the carbon atoms to which they are joined complete a substituted or unsubstituted carbocyclic ring, and X is a bond or an oxygen atom, is combined with a pharmaceutically acceptable, nontoxic inert diluent or carrier. Those compounds wherein R1, R2, R3 and R4 are not all simultaneously hydrogen are novel. When X is a bond, the compounds may be prepared by reacting an appropriately substituted 3-dyanomethylene phthalide with a base and, thereafter, if desired, converting the compound to a salt. When X is an oxygen atom, the compounds may be prepared by reacting a suitably substituted benzene derivative with an activated carbonyl group having a carbanion of the formula NC--CH--R, wherein R is a carboxylic acid ester group, and thereafter, if desired, converting the compound into a salt.
