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8-Hydroxyguanine, a derivative of guanine, is a highly reactive and mutagenic molecule formed by the oxidation of guanine, especially in the presence of reactive oxygen species. It is a major DNA lesion and biomarker of oxidative stress, linked to various diseases such as cancer and neurodegenerative disorders. The presence of 8-hydroxyguanine in DNA serves as an indicator of oxidative damage, playing a significant role in the development of mutations, genomic instability, and impacting cellular functions and aging.

5814-64-2

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5814-64-2 Usage

Uses

Used in Biomarker Detection:
8-Hydroxyguanine is used as a biomarker for oxidative stress in various applications, including the assessment of DNA damage and the development of potential therapeutic strategies.
Used in Research and Development:
In the field of molecular biology and genetics, 8-Hydroxyguanine is used as a research tool to study the molecular mechanisms of disease, the role of oxidative stress in mutagenesis, and the development of genomic instability.
Used in Diagnostics:
8-Hydroxyguanine is utilized in diagnostic applications to detect and monitor the presence of oxidative DNA damage, which can be indicative of various diseases and conditions.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 8-Hydroxyguanine is used as a target for the development of drugs aimed at reducing oxidative stress and its associated health risks, potentially leading to treatments for cancer and neurodegenerative disorders.
Used in Environmental Monitoring:
8-Hydroxyguanine can be employed in environmental studies to assess the impact of pollutants and other environmental factors on DNA integrity and oxidative stress levels in various organisms.
Used in Aging Research:
In the field of gerontology, 8-Hydroxyguanine is used to study the relationship between oxidative stress, DNA damage, and the aging process, contributing to the understanding of age-related diseases and the development of anti-aging therapies.

Check Digit Verification of cas no

The CAS Registry Mumber 5814-64-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,8,1 and 4 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 5814-64:
(6*5)+(5*8)+(4*1)+(3*4)+(2*6)+(1*4)=102
102 % 10 = 2
So 5814-64-2 is a valid CAS Registry Number.

5814-64-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-HYDROXYGUANINE

1.2 Other means of identification

Product number -
Other names 8-OH-GUA

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5814-64-2 SDS

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