5814-64-2

Basic information

• Product Name: 8-HYDROXYGUANINE
• Synonyms: 2-AMINO-7,9-DIHYDRO-1H-PURINE-6,8-DIONE;2-AMINO-6,8-DIHYDROXYPURINE;2-AMINO-6,8-PURINEDIOL;7,8-DIHYDRO-8-OXOGUANINE;8-OXOG;8-OXOGUANINE;8-OH-GUA;8-HYDROXYGUANINE
• CAS NO: 5814-64-2
• Molecular Formula: C5H5N5O2
• Molecular Weight: 167.13
• Mol File: 5814-64-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 784.7 °C at 760 mmHg
• Flash Point: 428.4 °C
• Appearance: /
• Density: 2.52 g/cm³
• Water Solubility: at 25 deg C (mg/L): 1e+006
• CAS DataBase Reference: 8-HYDROXYGUANINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-HYDROXYGUANINE(5814-64-2)
• EPA Substance Registry System: 8-HYDROXYGUANINE(5814-64-2)

Safety Data

• Hazardous Substances Data: 5814-64-2(Hazardous Substances Data)

Usage

General Description

8-Hydroxyguanine is a chemical compound that is derived from guanine, one of the four nucleobases found in DNA. It is a highly reactive and mutagenic molecule that is formed by the oxidation of guanine, particularly in the presence of reactive oxygen species. 8-Hydroxyguanine is considered a major DNA lesion and biomarker of oxidative stress and is associated with various diseases, including cancer and neurodegenerative disorders. It has been widely studied for its potential role in the development of mutations and genomic instability, as well as its impact on cellular functions and aging. The presence of 8-hydroxyguanine in DNA is used as an indicator of oxidative damage and has implications for understanding the molecular mechanisms of disease and for the development of potential therapeutic strategies.