58144-68-6Relevant academic research and scientific papers
Facile synthesis of disubstituted isoxazoles from homopropargylic alcohol via C=N bond formation
Gao, Pin,Li, Hong-Xia,Hao, Xin-Hua,Jin, Dong-Po,Chen, Dao-Qian,Yan, Xiao-Biao,Wu, Xin-Xing,Song, Xian-Rong,Liu, Xue-Yuan,Liang, Yong-Min
, p. 6298 - 6301 (2014)
A novel iron-catalyzed aerobic oxidative reaction to synthesize disubstituted isoxazoles from homopropargylic alcohol, t-BuONO, and H2O is developed. The method provides mild conditions to afford a variety of useful substituted heterocycles in an efficient and regioselective manner. The mechanism has been studied and proposed, which indicates that the transformation can be realized through construction of a C=N bond and C=O bond, C-H oxidation, and then cyclization. Moreover, this method can be enlarged to gram scale.
