58148-17-7Relevant articles and documents
Pd(II)-Catalyzed Enantioselective C(sp3)-H Borylation
He, Jian,Shao, Qian,Wu, Qingfeng,Yu, Jin-Quan
supporting information, p. 3344 - 3347 (2017/03/15)
Pd(II)-catalyzed enantioselective borylation of C(sp3)-H bonds has been realized for the first time using chiral acetyl-protected aminomethyl oxazoline ligands. This reaction is compatible with carbocyclic amides containing α-tertiary as well as α-quaternary carbon centers. The chiral β-borylated amides are useful synthons for the synthesis of chiral β-hydroxylated, β-fluorinated, and β-arylated carboxylic acids.
Palladium(II)-catalyzed enantioselective C(sp3)-H activation using a chiral hydroxamic acid ligand
Xiao, Kai-Jiong,Lin, David W.,Miura, Motofumi,Zhu, Ru-Yi,Gong, Wei,Wasa, Masayuki,Yu, Jin-Quan
, p. 8138 - 8142 (2014/06/23)
An enantioselective method for Pd(II)-catalyzed cross-coupling of methylene β-C(sp3)-H bonds in cyclobutanecarboxylic acid derivatives with arylboron reagents is described. High yields and enantioselectivities were achieved through the development of chiral mono-N-protected α-amino-O- methylhydroxamic acid (MPAHA) ligands, which form a chiral complex with the Pd(II) center. This reaction provides an alternative approach to the enantioselective synthesis of cyclobutanecarboxylates containing α-chiral quaternary stereocenters. This new class of chiral catalysts also show promises for enantioselective β-C(sp3)-H activation of acyclic amides.
