58149-50-1Relevant academic research and scientific papers
Water-soluble organotellurium compounds: Catalytic protection against peroxynitrite and release of zinc from metallothionein
Jacob, Claus,Arteel, Gavin E.,Kanda, Takahiro,Engman, Lars,Sies, Helmut
, p. 3 - 9 (2000)
The antioxidant properties of a number of water-soluble diorganyl tellurides have been investigated. These organotellurium compounds efficiently protect against peroxynitrite-mediated oxidation of dihydrorhodamine 123, hydroxylation of benzoate, and nitra
Substituent effects on the electronic structure of the flat Blatter radical: Correlation analysis of experimental and computational data
Bartos, Paulina,Chrostowska, Anna,Hande, Aniket A.,Kaszyński, Piotr,Pietrzak, Anna
supporting information, p. 22876 - 22887 (2021/12/24)
A series of C(10)-substituted derivatives of 2-Ph-3H-[1,2,4]triazino[5,6,1-kl]phenoxazin-3-yl was obtained using the aza-Pschorr, photochemical and radical-induced cyclization reactions, and through functional group transformations of the C(10)-amino and C(10)-iodo derivatives. The iodo derivative underwent Pd-catalyzed C-C cross coupling reactions leading to the installation of Ph, 2-thienyl and PhCC groups at the C(10) position effectively extending electronic conjugation. The substituent effect on the electronic properties of the 3H-[1,2,4]triazino[5,6,1-kl]phenoxazin-3-yl was investigated in twenty one derivatives with a diverse range of functional groups by spectroscopic (UV-vis and EPR) and electrochemical methods augmented with DFT calculations. Results show that the lowest energy electronic absorption and redox potentials correlate well with the σp substituent parameter, while aN hfcc and the N-H bond dissociation energy (BDE) are well described by the σm parameter. In general, increasing the electron donating ability of the C(10)-X substituent lowers the π-π?(1) excitation energy, cathodically shifts the redox potentials, increases spin delocalization beyond the [1,2,4]triazinyl ring and lowers BDE. The latter two parameters are important indicators of the overall radical stability. Molecular and crystal structures of three radicals were established with the single crystal XRD method. This journal is
Nitro-group-directed selective deacylation and desulfonation
Ji, Xiujie,Li, Chunbao
, p. 2478 - 2482 (2008/02/04)
Nitro-substituted phenolic esters and sulfonates were successfully and selectively deacylated and desulfonated, respectively. The directing effect of the nitro group is supported by the excellent regioselectivities and good yields. These reactions demonst
The Design and Properties of a Series of Calcium Indicators which Shift from Rhodamine-like to Fluorescein-like Fluorescence on Binding Calcium
Smith, Gerry A.,Metcalfe, James C.,Clarke, Sonia D.
, p. 1195 - 1204 (2007/10/02)
The prototype for a new series of ratio-mode fluorescence indicators of cytosolic free Ca2+ concentration (2+>i) has been developed.The fluorophore, termed FluoRhod, is a hybrid containing elements of the closely related fluorescein and rhodamine structures.The novel feature of the prototype indicator, FluoRhod-2, which incorporates a tetracarboxylate chelating element similar to that of 1,2-bisethane-N,N,N',N'-tetraacetic acid (BAPTA), is that it shifts from rhodamine- to fluorescein-like fluorescence on binding Ca2+.The synthesis and properties of a series of tetracarboxylate derivatives of the FluoRhod fluorophore are described which led to the FluoRhod-2 structure with an apparent dissociation constant for Ca2+ and pKa adjusted to meet the requirements for a 2+>i indicator in the ratio mode.The excitation and emission maxima of FluoRhod-2 are 537 nm and 566 nm in the absence of Ca2+ and 480 nm and 537 nm in the presence of Ca2+.The indicator can be used in either the dual excitation or dual emission mode or the ratio of these two ratios can be used by making dual excitation and dual emission measurements.The brightness of FluoRhod-2 is comparable to that of fura-2 with the advantage of excitation in the visible range.FluoRhod-2 is insensitive to pH from 6.5 to 7.5 when used in the ratio mode, irrespective of the extent to which the indicator is complexed to Ca2+.
