5815-64-5

Basic information

• Product Name: 1-[(2-chlorobenzyl)sulfonyl]-4-methylpiperidine
• Synonyms: piperidine, 1-[[(2-chlorophenyl)methyl]sulfonyl]-4-methyl-
• CAS NO: 5815-64-5
• Molecular Formula: C₁₂H₁₆N₂O₂
• Molecular Weight: 287.8055
• Mol File: 5815-64-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 414.5°C at 760 mmHg
• Flash Point: 204.5°C
• Density: 1.28g/cm³
• Vapor Pressure: 4.43E-07mmHg at 25°C
• Refractive Index: 1.58
• PKA: 14.47±0.70(Predicted)
• CAS DataBase Reference: 1-[(2-chlorobenzyl)sulfonyl]-4-methylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(2-chlorobenzyl)sulfonyl]-4-methylpiperidine(5815-64-5)
• EPA Substance Registry System: 1-[(2-chlorobenzyl)sulfonyl]-4-methylpiperidine(5815-64-5)

Safety Data

• Hazardous Substances Data: 5815-64-5(Hazardous Substances Data)

Upstream product

• 3235-82-3 N-morpholylacetic acid ethyl ester 
• 98-95-3 nitrobenzene 
• 110-91-8 morpholine 
• 4746-61-6 glycolanilide 

Relevant articles and documents

Chromium-Catalyzed Activation of Acyl C-O Bonds with Magnesium for Amidation of Esters with Nitroarenes

Here, we report a chromium-catalyzed activation of acyl C-O bonds with magnesium for amidation of esters with nitroarenes. Low-cost chromium(III) chloride shows high reactivity in promoting amidation by using magnesium as reductant and chlorotrimethylsilane as additive. It provides a step-economic strategy to the synthesis of centrally important amide motifs using inexpensive and air-stable nitroarenes as amino sources.