5816-39-7Relevant academic research and scientific papers
Magnesium chloride (MgCl2) catalyzed highly regioselective C-3 ring opening of 2,3 epoxy alcohols by N-nucleophile
Kumar, Amit,Panda, Gautam
supporting information, (2021/04/09)
We herein report Magnesium chloride (MgCl2) catalyzed first highly C3-selective ring-opening reaction of various 2,3-epoxy alcohols with assorted N-Nucleophiles and sodium azide to furnish 3-amino-1,2 diols and 3-azido-1,2 diols respectively in high yields under mild reaction conditions. This protocol attributes the use of catalytic amount of Magnesium chloride (MgCl2), simple reaction conditions, practical operation and broad functional group tolerance.
Tungsten-catalyzed regioselective and stereospecific ring opening of 2,3-epoxy alcohols and 2,3-epoxy sulfonamides
Wang, Chuan,Yamamoto, Hisashi
supporting information, p. 6888 - 6891 (2014/06/09)
The first catalytic, highly C3-selective, stereosepecific ring-opening reaction of 2,3-epoxy alcohols and 2,3-epoxy sulfonamides has been accomplished. This process was efficiently promoted by W-salts, and the developed method was applicable to various epoxides with diverse N-and O-nucleophiles affording the products in good to excellent yields (up to 95%) and generally with high regioselectivities (C3:C2 up to >99:1).
Tungsten-catalyzed regio- and enantioselective aminolysis of trans-2,3-epoxy alcohols: An entry to virtually enantiopure amino alcohols
Wang, Chuan,Yamamoto, Hisashi
supporting information, p. 13920 - 13923 (2015/02/05)
The first catalytic enantioselective aminolysis of trans-2,3-epoxy alcohols has been accomplished. This stereo-specific ring-opening process was efficiently promoted by a tungsten/bis(hydroxamic acid) catalytic system, furnishing various anti-3-amino-1,2-diols with excellent regiocontrol and high enantioselectivities (up to 95% ee). Moreover, virtually enantiopure 3-amino-1,2-diols could be obtained by the sequential combination of two reactions that both involve the use of a chiral catalyst.
The selective C-3 opening of aromatic 2,3-epoxy alcohols/epoxides with aromatic amines catalysed by β-cyclodextrin in water
Surendra,Krishnaveni, N. Srilakshmi,Rao, K. Rama
, p. 506 - 510 (2007/10/03)
A simple and mild procedure has been developed for the first time for the C-3 selective ring-opening of aromatic 2,3-epoxy alcohols/epoxides with aromatic amines catalysed by β-cyclodextrin in water at room temperature to afford the corresponding β-aminoa
