58177-71-2Relevant academic research and scientific papers
New efficient nickel-catalyzed cross-coupling reaction between two Csp3 centers
Giovannini,Strudemann,Devasagayaraj,Dussin,Knochel
, p. 3544 - 3553 (1999)
The presence of a remote unsaturation (double bond, carbonyl group, cyano group) in an alkyl halide facilitates its cross-coupling reaction with various diorganozincs in the presence of Ni(acac)2 (7.5-10 mol % in THF/NMP mixtures). These results were used to develop a new general cross-coupling reaction between functionalized diorganozincs and alkyl iodides using m- or p-trifluoromethylstyrene as a reaction promotor and Ni(acac)2 as a catalyst (7.5-10 mol %; -35 °C, 5-10 h) leading to a broad range of polyfunctional cross-coupling products.
Eine neue nickelkatalysierte Kreuzkupplung zwischen sp3-C-Zentren
Devasagayaraj, Arokiasamy,Stuedemann, Thomas,Knochel, Paul
, p. 2952 - 2954 (2007/10/03)
Keywords: Alkenkomplexe; Katalyse; Kreuzkupplung; Nickelverbindungen; Zinkverbindungen
TRANSITION METHAL-CATALYZED SUBSTITUTION REACTION OF ALLYLIC PHOSPHATES WITH GRIGNARD REAGENTS
Yanagisawa, Akira,Nomura, Nobuyoshi,Yamamoto, Hisashi
, p. 6017 - 6028 (2007/10/02)
SN2-selective Grignard coupling with primary allylic diphenylphosphates was successfully achieved using Ni or Fe catalyst.In sharp contrast, a catalytic amount of CuCN*2LiCl promoted a SN2'-selective coupling reaction.In the presence of the copper catalyst, stereochemically homogeneous γ-disubstituted allyl Grignard reagents reacted at the less substituted allylic terminus (α-position) with an allylic diphenylphosphate selectively without losing the double bond geometry.
REACTIVITY OF RCu,BF3 AND R2CuLi,BF3 TOWARDS ALLYLIC ACETALS AND ETHERS
Ghribi, A.,Alexakis, A.,Normant, J. F.
, p. 3079 - 3082 (2007/10/02)
Organocopper and cuprate reagents associated with Lewis acids, are highly reactive towards allylic acetals and ethers.Displacements of the alkoxy group occurs by SN2' attack according to the various parameters of the reaction.
