581777-67-5

Upstream product

• 577968-61-7 3-benzyloxy-4-difluoromethoxyphenylacetonitrile 
• 577968-62-8 1-(3-benzyloxy-4-difluoromethoxyphenyl)cyclopen-3-ene-1-carbonitrile 

Downstream Products

• 401519-07-1 methyl {4-cyano-4-[4-(difluoromethoxy)-3-(2,3-dihydro-1H-inden-2-yloxy)phenyl]piperidin-1-yl}acetate 
• 401519-09-3 methyl {4-cyano-4-[3-(cyclobutylmethoxy)-4-(difluoromethoxy)phenyl]piperidin-1-yl}acetate 
• 401519-11-7 methyl {4-[3-butoxy-4-(difluoromethoxy)phenyl]-4-cyanopiperidin-1-yl}acetate 
• 401519-08-2 methyl {4-cyano-4-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]piperidin-1-yl}acetate 
• 401519-06-0 methyl {4-cyano-4-[3-(cyclobutyloxy)-4-(difluoromethoxy)phenyl]piperidin-1-yl}acetate 
• 401519-12-8 methyl {4-cyano-4-[4-(difluoromethoxy)-3-propoxyphenyl]piperidin-1-yl}acetate 
• 401519-13-9 methyl {4-cyano-4-[4-(difluoromethoxy)-3-isobutoxyphenyl]piperidin-1-yl}acetate 
• 401519-10-6 methyl {4-cyano-4-[4-(difluoromethoxy)-3-ethoxyphenyl]piperidin-1-yl}acetate 
• 401519-04-8 methyl {4-cyano-4-[4-(difluoromethoxy)-3-hydroxyphenyl]piperidin-1-yl}acetate 
• 401519-02-6 methyl {4-[3-(benzyloxy)-4-(difluoromethoxy)phenyl]-4-cyanopiperidin-1-yl}acetate 

Relevant academic research and scientific papers

Highly potent PDE4 inhibitors with therapeutic potential

Synthesis and biological evaluation of piperidine derivatives is reported. The hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system prompted us to design and synthesize a hydrophilic piperidine