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Z-Glycin-m-hydroxyanilid, also known as Z-Gly-3-OH-Phe, is a synthetic compound that serves as a peptide derivative. It is formed by the condensation of glycine, an amino acid, with m-hydroxyaniline, a derivative of aniline. The "Z" prefix in its name stands for the benzyloxycarbonyl (Cbz) protecting group, which is commonly used in peptide synthesis to prevent unwanted side reactions. Z-Glycin-m-hydroxyanilid is often utilized in the study of peptide synthesis, protein structure, and as a building block for the creation of more complex peptide sequences. It is also relevant in the field of medicinal chemistry, where it may be used to develop new drugs or to understand the interactions between peptides and biological targets.

58178-09-9

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58178-09-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 58178-09-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,1,7 and 8 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 58178-09:
(7*5)+(6*8)+(5*1)+(4*7)+(3*8)+(2*0)+(1*9)=149
149 % 10 = 9
So 58178-09-9 is a valid CAS Registry Number.

58178-09-9Relevant academic research and scientific papers

New κ3-PNN′- and κ4-PNN′O- polydentate ligands: Synthesis, coordination and structural studies

Elsegood, Mark R.J.,Sanchez-Ballester, Noelia M.,Smith, Martin B.

experimental part, p. 115 - 121 (2012/02/02)

The three-step synthesis of new mixed P/N/N′/O-donor ligands C 6H3(OH){2-NHC(O)CH2NCHC6H 4PPh2}(4-CH3) 3a·HH and C 6H4(OH){3-NHC(O)CH2NCHC6H 4PPh2} 3b·HH, by Schiff base condensation of the 1° amines C6H3(OH){2-NHC(O)CH2NH 2}(4-CH3) 2a or C6H4(OH){3-NHC(O) CH2NH2} 2b with C6H4(CHO)(2-PPh 2) in refluxing EtOH, is described. Reaction of 1 equiv. of 3a·HH or 3b·HH with MCl2(cod) (M = Pt, Pd; cod = cycloocta-1,5-diene) affords the κ2-PN-chelate complexes MCl2(3a·HH) (M = Pd 4a; M = Pt 4b) and MCl 2(3b·HH) (M = Pt 4c). The dichlorometal(II) complexes 4d and 4e, bearing instead a pendant 4-phenolic group, were similarly prepared (in >90% yield). Chloro-bridge cleavage of [Pd(μ-Cl)(η3-C 3H5)]2 with 3a·HH or 3b·HH gave the monocationic κ2-PN-chelate complexes [Pd(η3- C3H5)(3a·HH)]Cl 5a or [Pd(η3-C 3H5)(3b·HH)]Cl 5b, respectively. Elimination of cod, and single CH3 protonation, from Pt(CH3) 2(cod) upon reaction with 1 equiv. of 3a·HH or 3b·HH in C7H8 at room temperature afforded the neutral complexes C6H3(OH){2-NC(O)CH2NCHC6H 4PPh2Pt(CH3)}(4-CH3) 6a and C 6H4(OH){3-NC(O)CH2NCHC6H 4PPh2Pt(CH3)} 6b, respectively bearing a monoanionic (3a·H- or 3b·H-) κ3-PNN′-tridentate ligand. Amide and phenol deprotonation were readily achieved, using KOtBu as base, to give high yields of the κ4-PNN′O-tetradentate complexes C6H 3(O){2-NC(O)CH2NCHC6H4PPh 2Pd}(4-CH3) 7a and C6H3(O){2-NC(O) CH2NCHC6H4PPh2Pt}(4-CH3) 7b bearing the dianionic ligand 3a2-. All new compounds have been characterised by multinuclear NMR, FTIR, mass spectroscopy and microanalysis. Single crystal X-ray studies have been performed on compounds 1b·1.5CH2Cl2, 3b·HH·0.5Et 2O, 6b·CHCl3 and 7b·0.5Et2O.

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